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Query: TCEA1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCEA1 1 5.665 -0.560 0.790 -0.119 0.977 2.240 -0.032 0.136

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCEA1 Phosphorylation S97 0.484 0.281 _EPAITS(ph)QNSPEAR_
TCEA1 Phosphorylation T96 0.333 0.133 _KKEPAIT(ph)SQNSPEAR_
TCEA1 Phosphorylation S100 0.006 0.054 _KKEPAITSQNS(ph)PEAR_
TCEA1 Ubiquitylation K242 0.908 _NLTK(gl)EAIR_
TCEA1 Ubiquitylation K265 0.854 _TGGTQTDLFTCGK(gl)CK_

Background Information for TCEA1:


Pubmed-TCEA1 »
Uniprot-TCEA1 »
Biogrid-TCEA1 »
ProteomicsDB-TCEA1 »

Tumorportal-TCEA1 »
COSMIC-TCEA1 »
GenomeRNAi-TCEA1 »
Genecards-TCEA1


Protein-protein Interactions for TCEA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EED Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait BROX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD3B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCRA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC38A7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TCEA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TFS2M IPR017890 0.15
Category members TFIIS/CRSP70_N_sub IPR003617 0.13
Category members TFIIS_cen_dom IPR003618 0.09
Category members TFIIS_N IPR017923 0.01
Category members Znf_TFIIS IPR001222 0
Category members TFSII IPR006289 0
Category members TF_IIS-rel IPR016492 0


Protein complexes (CORUM database) featuring TCEA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TCEA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0032784 regulation of DNA-dependent transcription, elongation Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0003746 translation elongation factor activity Database 0.08
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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