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Query: TBCK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TBCK 0 -1.001 1.920 -1.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TBCK Phosphorylation S890 -0.025 0.175 _IKPTGLLTIPS(ph)PQI_
TBCK Ubiquitylation K756 -1.151 _ESIPLNDLK(gl)SEVSPR_

Background Information for TBCK:


Pubmed-TBCK »
Uniprot-TBCK »
Biogrid-TBCK »
ProteomicsDB-TBCK »

Tumorportal-TBCK »
COSMIC-TBCK »
GenomeRNAi-TBCK »
Genecards-TBCK


Protein-protein Interactions for TBCK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PCDHB15 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R21 Cat. description Hein, Mann, Cell 2015
Category members IP bait TBCK Cat. description Hein, Mann, Cell 2015
Category members IP bait IL6R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TBCK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rab-GTPase-TBC_dom IPR000195 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Rhodanese-like_dom IPR001763 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TBCK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TBCK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005097 Rab GTPase activator activity Database 0.3
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0032313 regulation of Rab GTPase activity Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0


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