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Query: TAP1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TAP1 0 2.404 -1.000 1.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TAP1 Ubiquitylation K458 1.364 _LQEIK(gl)TLNQK_
TAP1 Ubiquitylation K449 1.133 _SFANEEGEAQK(gl)FR_

Background Information for TAP1:


Pubmed-TAP1 »
Uniprot-TAP1 »
Biogrid-TAP1 »
ProteomicsDB-TAP1 »

Tumorportal-TAP1 »
COSMIC-TAP1 »
GenomeRNAi-TAP1 »
Genecards-TAP1


Protein-protein Interactions for TAP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AR Cat. description Hein, Mann, Cell 2015
Category members IP bait ATL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait LTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait SIDT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBGCP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait GRPR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TAP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members ABC1_TM_dom IPR011527 0.33
Category members ABC_transporter-like IPR003439 0.15
Category members Ag_transporter2 IPR005293 0.15
Category members ABC_B2 IPR013305 0.15
Category members ABC_transptr_TM_dom IPR001140 0.06


Protein complexes (CORUM database) featuring TAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0019060 intracellular transport of viral protein in host cell Database 0.76
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0006952 defense response Database 0.32
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Disease phenotype BARE_LYMPHOCYTE_SYNDROME_TYPE_I BARE LYMPHOCYTE SYNDROME TYPE I Database 0.15
Category members GO Category GO:0046967 cytosol to ER transport Database 0.15
Category members Pathway Pathway_756 KEGG_ABC_TRANSPORTERS 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0015421 oligopeptide-transporting ATPase activity Database 0.11
Category members GO Category GO:0015833 peptide transport Database 0.11
Category members GO Category GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I Database 0.11
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0042626 ATPase activity, coupled to transmembrane movement of substances Database 0.09
Category members GO Category GO:0015197 peptide transporter activity Database 0.04
Category members GO Category GO:0042825 TAP complex Database 0.04
Category members GO Category GO:0046978 TAP1 binding Database 0.04
Category members GO Category GO:0046979 TAP2 binding Database 0.04
Category members GO Category GO:0046980 tapasin binding Database 0.04
Category members Pathway Pathway_207 KEGG_PRIMARY_IMMUNODEFICIENCY 0 0
Category members GO Category GO:0001916 positive regulation of T cell mediated cytotoxicity Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0030176 integral to endoplasmic reticulum membrane Database 0
Category members GO Category GO:0042288 MHC class I protein binding Database 0
Category members GO Category GO:0042605 peptide antigen binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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