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Query: SUPT5H

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SUPT5H 2 10.123 -0.200 -0.640 1.025 -0.578 1.307 -1.339 0.255

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SUPT5H Ubiquitylation K274 0.337 1.786 _EVANLK(gl)PK_
SUPT5H Phosphorylation T806 0.883 _TPHYGSQT(ph)PLHDGSR_
SUPT5H Phosphorylation S671 -0.479 0.444 _ISS(ph)PMHPSAGGQR_
SUPT5H Phosphorylation S666 -0.471 -0.100 _DVTNFTVGGFAPMS(ph)PR_
SUPT5H Phosphorylation S32 -1.198 _S(ph)AAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPK_
SUPT5H Ubiquitylation K143 0.325 _DQREEELGEYYMK(gl)K_
SUPT5H Ubiquitylation K144 0.325 _DQREEELGEYYMK(gl)K_
SUPT5H Ubiquitylation K231 1.246 _GYIYVEAYK(gl)QTHVK_
SUPT5H Ubiquitylation K323 1.006 _MSLK(gl)DWFAK_
SUPT5H Ubiquitylation K627 0.092 _SFAFLHCK(gl)K_
SUPT5H Ubiquitylation K628 0.092 _SFAFLHCK(gl)K_
SUPT5H Ubiquitylation K650 -0.223 _HLVLAGGSK(gl)PR_
SUPT5H Ubiquitylation K718 0.094 _ISQGPYK(gl)GYIGVVK_
SUPT5H Ubiquitylation K1017 -0.116 _SVTGGMCSVYLK(gl)DSEK_
SUPT5H Phosphorylation T1036 5.538 _VVSISSEHLEPITPT(ph)K_
SUPT5H Ubiquitylation K1037 -1.487 _VVSISSEHLEPITPTK(gl)NNK_

Background Information for SUPT5H:


Pubmed-SUPT5H »
Uniprot-SUPT5H »
Biogrid-SUPT5H »
ProteomicsDB-SUPT5H »

Tumorportal-SUPT5H »
COSMIC-SUPT5H »
GenomeRNAi-SUPT5H »
Genecards-SUPT5H


Protein-protein Interactions for SUPT5H
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C17orf85 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IWS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait LEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait WHSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRNPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLEKHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SUPT5H
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Translation_prot_SH3-like IPR008991 0.29
Category members KOW IPR005824 0.16


Protein complexes (CORUM database) featuring SUPT5H
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1191 RNA pol II containing coactivator complex Tat-SF Database 2.13
Category members Corum 2603 Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) Database 0.7
Category members Corum 2860 DSIF complex (DRB sensitivity-inducing factor complex) Database 0.05
Category members Corum 2861 DSIF complex (DRB sensitivity-inducing factor complex) Database 0.05


Categories featuring SUPT5H
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0032786 positive regulation of DNA-dependent transcription, elongation Database 1.27
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_364 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT 0 0.35
Category members GO Category GO:0032784 regulation of DNA-dependent transcription, elongation Database 0.33
Category members GO Category GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016239 positive regulation of macroautophagy Database 0.09
Category members GO Category GO:0032044 DSIF complex Database 0.05
Category members GO Category GO:0032785 negative regulation of DNA-dependent transcription, elongation Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0006354 DNA-dependent transcription, elongation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010033 response to organic substance Database 0


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