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Query: STX6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STX6 1 3.381 -1.950 3.000

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STX6 Ubiquitylation K139 0.381 _QALLGDSGSQNWSTGTTDK(gl)YGR_
STX6 Ubiquitylation K221 -0.371 _LDNVMKK(gl)_

Background Information for STX6:


Pubmed-STX6 »
Uniprot-STX6 »
Biogrid-STX6 »
ProteomicsDB-STX6 »

Tumorportal-STX6 »
COSMIC-STX6 »
GenomeRNAi-STX6 »
Genecards-STX6


Protein-protein Interactions for STX6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SNAP29 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLEC12A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM171B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAUS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SEC22B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STXBP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM200A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAMP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STX6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members T_SNARE_dom IPR000727 0.54
Category members Syntaxin-6_N IPR015260 0.11
Category members t-SNARE IPR010989 0.04


Protein complexes (CORUM database) featuring STX6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 874 SNARE complex (VAMP3, VAMP4, VAMP8, STX6) Database 0.62
Category members Corum 820 SNARE complex (STX6, SNAP23) Database 0.13
Category members Corum 876 SNARE complex (VAMP3, STX6, VTI1A) Database 0
Category members Corum 877 SNARE complex (VAMP4, STX6, STX16, VTI1a, VTI1b) Database 0


Categories featuring STX6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_1261 KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 0 1.52
Category members GO Category GO:0006906 vesicle fusion Database 1.28
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0031201 SNARE complex Database 0.49
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0042147 retrograde transport, endosome to Golgi Database 0.26
Category members Pathway Pathway_1262 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 0 0.2
Category members GO Category GO:0005484 SNAP receptor activity Database 0.2
Category members GO Category GO:0048193 Golgi vesicle transport Database 0.19
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members Pathway Pathway_1263 REACTOME_BOTULINUM_NEUROTOXICITY 0 0.07
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0032588 trans-Golgi network membrane Database 0.05
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0


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