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Query: STAG2

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STAG2 0 4.980 0.690 -0.320
STAG2 0 4.980 0.690 -0.320 1.092 0.608
STAG2 0 4.980 0.690 -0.320 0.933 0.143 0.415

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STAG2 Phosphorylation T1112 0.806 _EQTLHT(ph)PVMMQTPQLTSTIMR_
STAG2 Phosphorylation S1061 0.668 0.663 _NSLLAGGDDDTMSVIS(ph)GISSR_
STAG2 Phosphorylation S1065 0.596 _NSLLAGGDDDTM(ox)SVISGISS(ph)R_
STAG2 Ubiquitylation K270 -0.214 0.529 _LELLLQK(gl)R_
STAG2 Phosphorylation S1064 0.577 0.254 _NSLLAGGDDDTMSVISGIS(ph)SR_
STAG2 Phosphorylation T1197 0.563 0.120 _GT(ph)SLMEDDEEPIVEDVMMSSEGR_
STAG2 Ubiquitylation K755 0.039 _ITESSSTK(gl)EDLLR_
STAG2 Phosphorylation S1198 0.563 0.016 _GTS(ph)LM(ox)EDDEEPIVEDVMMSSEGR_
STAG2 Ubiquitylation K449 -0.454 _RDPEEDGMMK(gl)R_

Background Information for STAG2:


Pubmed-STAG2 »
Uniprot-STAG2 »
Biogrid-STAG2 »
ProteomicsDB-STAG2 »

Tumorportal-STAG2 »
COSMIC-STAG2 »
GenomeRNAi-STAG2 »
Genecards-STAG2


Protein-protein Interactions for STAG2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAD21 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait WAPAL Cat. description Hein, Mann, Cell 2015
Category members IP bait ALDH3A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR183 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP5K1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STAG2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members STAG IPR013721 0.11


Protein complexes (CORUM database) featuring STAG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 163 Cohesin-SA2 complex Database 1.44
Category members Corum 166 Cohesin-SA2 complex Database 1.44
Category members Corum 64 Mitotic 14S cohesin 2 complex Database 1.44


Categories featuring STAG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0032876 negative regulation of DNA endoreduplication Database 1.09
Category members GO Category GO:0007062 sister chromatid cohesion Database 0.69
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0007126 meiosis Database 0.01


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