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Query: SRSF2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
SRSF2	1	4.852	0.230	-0.340
SRSF2	1	4.852	0.230	-0.340	0.316	0.700	-0.680	-0.119	-0.358

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
SRSF2	Ubiquitylation	K63	1.341	1.921	_VFEK(gl)YGR_
SRSF2	Phosphorylation	T29		0.970	_VDNLTYRTSPDT(ph)LR_
SRSF2	Phosphorylation	S26	0.636	0.891	_VDNLTYRTS(ph)PDTLR_
SRSF2	Phosphorylation	T22	0.740	0.763	_VDNLT(ph)YRTSPDTLR_
SRSF2	Phosphorylation	T25	0.781	0.654	_VDNLTYRT(ph)SPDTLR_
SRSF2	Phosphorylation	S2	-0.541	0.173	_(ac)S(ph)YGRPPPDVEGMTSLK_
SRSF2	Phosphorylation	S182	-0.171	-0.115	_SKS(ph)PPKSPEEEGAVSS_

Background Information for SRSF2:

Pubmed-SRSF2 »

Uniprot-SRSF2 »

Biogrid-SRSF2 »

ProteomicsDB-SRSF2 »

Tumorportal-SRSF2 »

COSMIC-SRSF2 »

GenomeRNAi-SRSF2 »

Genecards-SRSF2

Protein-protein Interactions for SRSF2

Show screen data for	Category Name and Description	Link to cat description	Data Source

Protein Domains in SRSF2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	RRM_dom	IPR000504	4.34
Category members	RRM_dom_euk	IPR003954	0.18

Protein complexes (CORUM database) featuring SRSF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	351	Spliceosome	Database	9.3
Category members	Corum	1183	CDC5L complex	Database	2.07

Categories featuring SRSF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0003723	RNA binding	Database	INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0010467	gene expression	Database	INF
Category members	Pathway	Pathway_373	REACTOME_MRNA_PROCESSING	0	12.92
Category members	Pathway	Pathway_380	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	0	12.24
Category members	GO Category	GO:0008380	RNA splicing	Database	10.77
Category members	Pathway	Pathway_348	REACTOME_TRANSCRIPTION	0	9
Category members	Pathway	Pathway_851	KEGG_SPLICEOSOME	0	7.94
Category members	GO Category	GO:0000398	mRNA splicing, via spliceosome	Database	7.06
Category members	Pathway	Pathway_377	REACTOME_MRNA_SPLICING	0	6.99
Category members	Pathway	Pathway_878	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	0	6.53
Category members	GO Category	GO:0000166	nucleotide binding	Database	5.91
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	GO Category	GO:0016607	nuclear speck	Database	4.84
Category members	GO Category	GO:0006406	mRNA export from nucleus	Database	4.09
Category members	GO Category	GO:0006397	mRNA processing	Database	3.76
Category members	Pathway	Pathway_375	REACTOME_RNA_POL_II_TRANSCRIPTION	0	2.46
Category members	Pathway	Pathway_852	REACTOME_MRNA_3_END_PROCESSING	0	2.02
Category members	Pathway	Pathway_372	REACTOME_MRNA_SPLICING_MINOR_PATHWAY	0	1.52
Category members	GO Category	GO:0006366	transcription from RNA polymerase II promoter	Database	0.96
Category members	Pathway	Pathway_854	REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_	0	0.91
Category members	GO Category	GO:0031124	mRNA 3'-end processing	Database	0.91
Category members	GO Category	GO:0006369	termination of RNA polymerase II transcription	Database	0.87
Category members	GO Category	GO:0003676	nucleic acid binding	Database	0.83
Category members	GO Category	GO:0003714	transcription corepressor activity	Database	0