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Query: SPTB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPTB 2 4.059 -0.050 0.120
SPTB 2 4.059 -0.050 0.120 0.059 -0.418 -0.700 0.255 0.415

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPTB Ubiquitylation K2269 1.563 1.748 _EAVCEVALDYK(gl)K_
SPTB Ubiquitylation K2270 1.484 1.748 _EAVCEVALDYKK(gl)_
SPTB Phosphorylation S2114 0.318 _TS(ph)PVSLWSR_
SPTB Phosphorylation S2319 0.406 0.012 _HEVSASTQS(ph)TPASSR_
SPTB Phosphorylation S2338 -0.151 _AQTLPTSVVTITS(ph)ESSPGK_
SPTB Phosphorylation S2340 -0.260 -0.175 _AQTLPTSVVTITSES(ph)SPGKR_
SPTB Phosphorylation T2335 -0.213 _AQTLPTSVVT(ph)ITSESSPGKR_
SPTB Ubiquitylation K593 -1.044 -0.240 _GVNASAQK(gl)FATDGEGYKPCDPQVIR_
SPTB Phosphorylation T2320 0.156 -0.264 _HEVSASTQST(ph)PASSR_
SPTB Phosphorylation S2341 -0.329 -0.373 _AQTLPTSVVTITSESS(ph)PGK_
SPTB Phosphorylation S2102 -0.534 -0.677 _RPPS(ph)PEPSTK_
SPTB Ubiquitylation K2344 1.728 -0.691 _AQTLPTSVVTITSESSPGK(gl)R_
SPTB Ubiquitylation K105 -0.685 _LPKPTK(gl)GR_
SPTB Ubiquitylation K924 0.362 _QLMHSGHPSEK(gl)EIK_
SPTB Ubiquitylation K1532 -0.807 _NQTLQK(gl)EIQGHQPR_
SPTB Ubiquitylation K2177 0.394 _AK(gl)TALPAQSAATLPAR_
SPTB Phosphorylation T2317 -0.391 _HEVSAST(ph)QSTPASSR_
SPTB Ubiquitylation K2362 1.856 _FSLFGK(gl)K_
SPTB Ubiquitylation K2363 1.856 _FSLFGK(gl)K_

Background Information for SPTB:


Pubmed-SPTB »
Uniprot-SPTB »
Biogrid-SPTB »
ProteomicsDB-SPTB »

Tumorportal-SPTB »
COSMIC-SPTB »
GenomeRNAi-SPTB »
Genecards-SPTB


Protein-protein Interactions for SPTB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CPLX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLB1L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NMNAT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40AL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPTB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members PH_domain IPR001849 0.14
Category members CAMSAP_CH IPR022613 0.13
Category members Spectrin_bsu IPR016343 0.04
Category members PH_dom-spectrin-type IPR001605 0


Protein complexes (CORUM database) featuring SPTB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPTB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008091 spectrin Database 0.43
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members Disease phenotype Hereditary_spherocytosis Hereditary spherocytosis Database 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1287 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 0 0
Category members Disease phenotype ELLIPTOCYTOSIS_2 ELLIPTOCYTOSIS 2 Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0006779 porphyrin-containing compound biosynthetic process Database 0
Category members GO Category GO:0007009 plasma membrane organization Database 0
Category members GO Category GO:0014731 spectrin-associated cytoskeleton Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030506 ankyrin binding Database 0
Category members GO Category GO:0031235 intrinsic to cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0051693 actin filament capping Database 0


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