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Query: SPG11

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPG11 0 0.052 1.830 -1.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPG11 Ubiquitylation K2208 0.052 _TALLDYIK(gl)R_
SPG11 Ubiquitylation K1300 -0.516 _ESVAEK(gl)LSK_
SPG11 Ubiquitylation K981 -0.707 _IGGVIQDTLPVQNYK(gl)TK_
SPG11 Ubiquitylation K353 -1.074 _AQLSSLNETIKNSK(gl)_
SPG11 Ubiquitylation K1724 -1.234 _HIEQWSLK(gl)QAR_
SPG11 Ubiquitylation K552 -1.385 _SK(gl)ENLFNPSSK_

Background Information for SPG11:


Pubmed-SPG11 »
Uniprot-SPG11 »
Biogrid-SPG11 »
ProteomicsDB-SPG11 »

Tumorportal-SPG11 »
COSMIC-SPG11 »
GenomeRNAi-SPG11 »
Genecards-SPG11


Protein-protein Interactions for SPG11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ELAVL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C4orf6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUDENG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPG11
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SPG11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPG11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Disease phenotype Juvenile_amyotrophic_lateral_sclerosis Juvenile amyotrophic lateral sclerosis Database 0.32
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0


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