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Query: SMC6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMC6 1 1.986 2.130 -1.240 0.240 0.345 -0.133 0.388

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMC6 Ubiquitylation K201 0.273 0.873 _QFLQSK(gl)NEGDKYK_
SMC6 Ubiquitylation K157 0.258 -0.355 _LK(gl)SATGSVVSTR_
SMC6 Ubiquitylation K107 -0.691 _GSSLK(gl)GFVK_

Background Information for SMC6:


Pubmed-SMC6 »
Uniprot-SMC6 »
Biogrid-SMC6 »
ProteomicsDB-SMC6 »

Tumorportal-SMC6 »
COSMIC-SMC6 »
GenomeRNAi-SMC6 »
Genecards-SMC6


Protein-protein Interactions for SMC6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait EID3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSMCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSMCE4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PJA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUFT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF597 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMC6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members RecF/RecN/SMC_N IPR003395 0


Protein complexes (CORUM database) featuring SMC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SMC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0030915 Smc5-Smc6 complex Database 0.15


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