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Query: SMC5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMC5 0 -1.539 -0.480 0.030 -0.134 0.484 -0.303 0.216

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMC5 Ubiquitylation K925 -1.832 _ENISQVK(gl)ER_

Background Information for SMC5:





Protein-protein Interactions for SMC5

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait SESN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EID3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSMCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSMCE4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PJA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF597 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMC5

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members RecF/RecN/SMC_N IPR003395 0


Protein complexes (CORUM database) featuring SMC5

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SMC5

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0030915 Smc5-Smc6 complex Database 0.15
Category members GO Category GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion Database 0
Category members GO Category GO:0045842 positive regulation of mitotic metaphase/anaphase transition Database 0


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