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Query: SMC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMC4 0 1.637 0.480 -0.480 0.146 -0.138 0.461 0.023 -0.067

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMC4 Ubiquitylation K607 0.339 _VLDAIIQEK(gl)K_
SMC4 Ubiquitylation K608 0.339 _VLDAIIQEK(gl)K_
SMC4 Phosphorylation S41 0.075 0.293 _TES(ph)PATAAETASEELDNR_
SMC4 Phosphorylation T48 0.032 0.292 _TES(ph)PATAAET(ph)ASEELDNR_
SMC4 Phosphorylation T39 0.060 _T(ph)ESPATAAETASEELDNR_
SMC4 Ubiquitylation K416 0.450 -0.040 _LEK(gl)QLQK_
SMC4 Ubiquitylation K202 -0.181 -0.066 _DNTSVYHISGK(gl)K_
SMC4 Ubiquitylation K207 -0.089 _TFK(gl)DVGNLLR_
SMC4 Phosphorylation S50 -0.579 -0.123 _TES(ph)PATAAETAS(ph)EELDNR_
SMC4 Phosphorylation T44 0.131 -0.179 _TESPAT(ph)AAETASEELDNR_
SMC4 Ubiquitylation K1273 -0.330 _TYNITK(gl)SVAVNPK_
SMC4 Ubiquitylation K968 -0.407 _SLEDK(gl)AAEVVK_
SMC4 Ubiquitylation K974 -0.407 _SLEDK(gl)AAEVVK_
SMC4 Ubiquitylation K1112 -0.254 -0.466 _VAELDK(gl)ITYER_
SMC4 Ubiquitylation K106 -0.826 -0.664 _ILGPFHK(gl)R_
SMC4 Ubiquitylation K268 -0.240 -0.861 _LNEPIK(gl)VLCR_
SMC4 Ubiquitylation K1285 -1.105 _EIASK(gl)GLC_
SMC4 Phosphorylation S22 -2.829 -1.797 _RREEGPPPPS(ph)PDGASSDAEPEPPSGR_
SMC4 Phosphorylation S28 -2.042 -2.174 _RREEGPPPPSPDGASS(ph)DAEPEPPSGR_
SMC4 Phosphorylation S27 -2.450 -3.129 _EEGPPPPSPDGAS(ph)SDAEPEPPSGR_
SMC4 Ubiquitylation K1187 0.176 _K(gl)IFNLSGGEK_

Background Information for SMC4:


Pubmed-SMC4 »
Uniprot-SMC4 »
Biogrid-SMC4 »
ProteomicsDB-SMC4 »

Tumorportal-SMC4 »
COSMIC-SMC4 »
GenomeRNAi-SMC4 »
Genecards-SMC4


Protein-protein Interactions for SMC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait SACM1L Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members RecF/RecN/SMC_N IPR003395 0
Category members Prefoldin IPR009053 0
Category members SMC_hinge IPR010935 0


Protein complexes (CORUM database) featuring SMC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 49 DNMT3B complex Database 1.05
Category members Corum 159 Condensin I-PARP-1-XRCC1 complex Database 0.12
Category members Corum 10 13S condensin complex Database 0
Category members Corum 157 Condensin I complex Database 0
Category members Corum 160 Condensin II Database 0
Category members Corum 167 Condensin I complex Database 0
Category members Corum 353 DNA ligase IV-condensin complex Database 0
Category members Corum 5239 CAP(C)-CAP(E) complex Database 0


Categories featuring SMC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0006935 chemotaxis Database 0.09
Category members GO Category GO:0007076 mitotic chromosome condensation Database 0.01
Category members GO Category GO:0045132 meiotic chromosome segregation Database 0.01
Category members GO Category GO:0000070 mitotic sister chromatid segregation Database 0
Category members GO Category GO:0000796 condensin complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010032 meiotic chromosome condensation Database 0
Category members GO Category GO:0051383 kinetochore organization Database 0


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