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Query: SKIV2L2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SKIV2L2 0 0.329 -0.700 0.990
SKIV2L2 0 0.329 -0.700 0.990 -0.408 -1.067 -0.153 -0.849 -0.141

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SKIV2L2 Ubiquitylation K192 0.854 _VIFTSPIK(gl)ALSNQK_
SKIV2L2 Ubiquitylation K873 0.279 _LGFATSSDVIEMK(gl)GR_
SKIV2L2 Ubiquitylation K198 0.245 _ALSNQK(gl)YR_
SKIV2L2 Ubiquitylation K852 0.044 _TVLQMDELK(gl)CR_
SKIV2L2 Ubiquitylation K768 1.102 -0.687 _SIQEVQK(gl)R_
SKIV2L2 Ubiquitylation K796 -0.319 _VIQK(gl)VEAFEHR_

Background Information for SKIV2L2:


Pubmed-SKIV2L2 »
Uniprot-SKIV2L2 »
Biogrid-SKIV2L2 »
ProteomicsDB-SKIV2L2 »

Tumorportal-SKIV2L2 »
COSMIC-SKIV2L2 »
GenomeRNAi-SKIV2L2 »
Genecards-SKIV2L2


Protein-protein Interactions for SKIV2L2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BOD1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF3C Cat. description Hein, Mann, Cell 2015
Category members IP bait MZT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA15 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZFC3H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SKIV2L2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members DSH_C IPR012961 0
Category members RNA_helicase_ATP-dep_SK12/DOB1 IPR016438 0


Protein complexes (CORUM database) featuring SKIV2L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring SKIV2L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members GO Category GO:0000460 maturation of 5.8S rRNA Database 0.29
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06


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