bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SIRT2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIRT2 0 1.232 0.960 -0.980

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIRT2 Ubiquitylation K142 0.842 1.458 _LLKDK(gl)GLLLR_
SIRT2 Ubiquitylation K140 0.154 1.067 _LLK(gl)DKGLLLR_
SIRT2 Ubiquitylation K39 0.138 0.076 _NLFSQTLSLGSQK(gl)ER_
SIRT2 Ubiquitylation K270 -0.520 _LLINK(gl)EK_
SIRT2 Phosphorylation S368 -0.366 -0.702 _EHASIDAQSGAGVPNPSTSAS(ph)PK_
SIRT2 Phosphorylation S364 -0.719 _EHASIDAQSGAGVPNPS(ph)TSASPK_
SIRT2 Phosphorylation S366 -0.826 _EHASIDAQSGAGVPNPSTS(ph)ASPK_

Background Information for SIRT2:


Pubmed-SIRT2 »
Uniprot-SIRT2 »
Biogrid-SIRT2 »
ProteomicsDB-SIRT2 »

Tumorportal-SIRT2 »
COSMIC-SIRT2 »
GenomeRNAi-SIRT2 »
Genecards-SIRT2


Protein-protein Interactions for SIRT2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DMD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSTT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSTT2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0930 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MOAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUDT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNAI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIRT2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Sirtuin IPR003000 0
Category members Sirtuin_class_I IPR017328 0
Category members Ssirtuin_cat_dom IPR026590 0
Category members DHS-like_NAD/FAD-binding_dom IPR029035 0


Protein complexes (CORUM database) featuring SIRT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SIRT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0000183 chromatin silencing at rDNA Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0006348 chromatin silencing at telomere Database 0.09
Category members GO Category GO:0070403 NAD+ binding Database 0.09
Category members GO Category GO:0007096 regulation of exit from mitosis Database 0.07
Category members GO Category GO:0042903 tubulin deacetylase activity Database 0.04
Category members GO Category GO:0016458 gene silencing Database 0.03
Category members GO Category GO:0005677 chromatin silencing complex Database 0
Category members GO Category GO:0006342 chromatin silencing Database 0
Category members GO Category GO:0006471 protein ADP-ribosylation Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Database 0
Category members GO Category GO:0017136 NAD-dependent histone deacetylase activity Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0034979 NAD-dependent protein deacetylase activity Database 0
Category members GO Category GO:0034983 peptidyl-lysine deacetylation Database 0
Category members GO Category GO:0035035 histone acetyltransferase binding Database 0
Category members GO Category GO:0042325 regulation of phosphorylation Database 0
Category members GO Category GO:0045843 negative regulation of striated muscle tissue development Database 0
Category members GO Category GO:0051775 response to redox state Database 0


.

© Copyright Svejstrup Laboratory 2015