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Query: SHMT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SHMT1 1 3.143 -0.120 0.930
SHMT1 1 3.143 -0.120 0.930 0.878 1.600 -2.560 0.964 0.784

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SHMT1 Ubiquitylation K356 1.096 _EYSLQVLK(gl)NAR_
SHMT1 Ubiquitylation K409 0.692 _VLELVSITANK(gl)NTCPGDR_
SHMT1 Ubiquitylation K469 -0.436 _LQDFK(gl)SFLLK_
SHMT1 Ubiquitylation K416 -0.549 -0.533 _GLLEK(gl)DFQK_
SHMT1 Ubiquitylation K103 -2.726 -0.554 _YSEGYPGK(gl)R_
SHMT1 Ubiquitylation K280 -0.564 _HADIVTTTTHK(gl)TLR_
SHMT1 Ubiquitylation K474 -1.113 -0.594 _SFLLK(gl)DSETSQR_
SHMT1 Ubiquitylation K72 -0.735 _AVLEALGSCLNNK(gl)YSEGYPGQR_
SHMT1 Ubiquitylation K386 -0.881 _VLEACSIACNK(gl)NTCPGDR_
SHMT1 Ubiquitylation K446 -1.125 _ATLK(gl)EFK_

Background Information for SHMT1:


Pubmed-SHMT1 »
Uniprot-SHMT1 »
Biogrid-SHMT1 »
ProteomicsDB-SHMT1 »

Tumorportal-SHMT1 »
COSMIC-SHMT1 »
GenomeRNAi-SHMT1 »
Genecards-SHMT1


Protein-protein Interactions for SHMT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C7orf60 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SHMT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser_HO-MeTrfase IPR001085 0
Category members Aminotransferase_I/II IPR004839 0
Category members Josephin IPR006155 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring SHMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SHMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0006544 glycine metabolic process Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008242 omega peptidase activity Database 0.28
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0016597 amino acid binding Database 0.11
Category members GO Category GO:0009058 biosynthetic process Database 0.11
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_20 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM 0 0
Category members GO Category GO:0004372 glycine hydroxymethyltransferase activity Database 0
Category members GO Category GO:0006545 glycine biosynthetic process Database 0
Category members GO Category GO:0006563 L-serine metabolic process Database 0
Category members GO Category GO:0006565 L-serine catabolic process Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0008732 L-allo-threonine aldolase activity Database 0
Category members GO Category GO:0009113 purine nucleobase biosynthetic process Database 0
Category members GO Category GO:0019264 glycine biosynthetic process from serine Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0035999 tetrahydrofolate interconversion Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045329 carnitine biosynthetic process Database 0
Category members GO Category GO:0046655 folic acid metabolic process Database 0


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