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Query: SHARPIN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SHARPIN 0 -1.368 1.240 -0.570

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SHARPIN Ubiquitylation K189 0.043 0.785 _AIAGGDEK(gl)GAAQVAAVLAQHR_
SHARPIN Phosphorylation S131 -0.955 -1.242 _S(ph)NSPPALGPEACPVSLPSPPEASTLK_
SHARPIN Phosphorylation S129 -0.955 -1.373 _S(ph)NSPPALGPEACPVSLPSPPEASTLK_
SHARPIN Ubiquitylation K318 -2.283 -2.114 _EAPATGPSPQHPQK(gl)MDGELGR_

Background Information for SHARPIN:


Pubmed-SHARPIN »
Uniprot-SHARPIN »
Biogrid-SHARPIN »
ProteomicsDB-SHARPIN »

Tumorportal-SHARPIN »
COSMIC-SHARPIN »
GenomeRNAi-SHARPIN »
Genecards-SHARPIN


Protein-protein Interactions for SHARPIN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait LIPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SHARPIN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Znf_RanBP2 IPR001876 0.18


Protein complexes (CORUM database) featuring SHARPIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SHARPIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0031593 polyubiquitin binding Database 0.38
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0031424 keratinization Database 0.04
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008544 epidermis development Database 0
Category members GO Category GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0030262 apoptotic nuclear changes Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0


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