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Query: SF3B3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SF3B3 2 7.472 -2.590 5.210 0.333 -0.136 0.248 -0.316 0.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SF3B3 Ubiquitylation K101 1.551 _NM(ox)FEK(gl)IHQETFGK_
SF3B3 Ubiquitylation K965 0.907 _VLIGVGK(gl)LLR_
SF3B3 Ubiquitylation K546 0.526 _TIVK(gl)CAVNQR_
SF3B3 Ubiquitylation K109 0.083 -0.137 _IHQETFGK(gl)SGCRR_
SF3B3 Ubiquitylation K1206 -1.861 _NVSEELDRTPPEVSK(gl)K_
SF3B3 Ubiquitylation K1207 -1.934 -1.861 _NVSEELDRTPPEVSKK(gl)_
SF3B3 Ubiquitylation K974 0.479 _VYDLGK(gl)KK_
SF3B3 Ubiquitylation K975 0.552 _VYDLGKK(gl)_
SF3B3 Ubiquitylation K1074 -1.824 _LPPNTNDEVDEDPTGNK(gl)ALWDR_

Background Information for SF3B3:


Pubmed-SF3B3 »
Uniprot-SF3B3 »
Biogrid-SF3B3 »
ProteomicsDB-SF3B3 »

Tumorportal-SF3B3 »
COSMIC-SF3B3 »
GenomeRNAi-SF3B3 »
Genecards-SF3B3


Protein-protein Interactions for SF3B3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC97 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SF3B3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members Cleavage/polyA-sp_fac_asu_C IPR004871 0.34


Protein complexes (CORUM database) featuring SF3B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 2755 17S U2 snRNP Database 1.77
Category members Corum 1413 NCOR1 complex Database 0.65
Category members Corum 475 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) Database 0.33
Category members Corum 430 18S U11/U12 snRNP Database 0.29
Category members Corum 476 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) Database 0.2
Category members Corum 1737 SF3b complex Database 0.08
Category members Corum 445 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 455 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 456 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 459 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 462 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 513 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.05
Category members Corum 470 TFTC complex (TATA-binding protein-free TAF-II-containing complex) Database 0.02


Categories featuring SF3B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000375 RNA splicing, via transesterification reactions Database 0.73
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0005689 U12-type spliceosomal complex Database 0.29
Category members GO Category GO:0030532 small nuclear ribonucleoprotein complex Database 0.15


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