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Query: RFWD3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RFWD3 0 -0.532 -0.420

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RFWD3 Ubiquitylation K364 -0.539 0.428 _SSLLK(gl)EQMLR_
RFWD3 Ubiquitylation K583 -0.907 -0.404 _NTSSHVQELVAQK(gl)AR_

Background Information for RFWD3:


Pubmed-RFWD3 »
Uniprot-RFWD3 »
Biogrid-RFWD3 »
ProteomicsDB-RFWD3 »

Tumorportal-RFWD3 »
COSMIC-RFWD3 »
GenomeRNAi-RFWD3 »
Genecards-RFWD3


Protein-protein Interactions for RFWD3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait EVPL Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNF41 Cat. description Hein, Mann, Cell 2015
Category members IP bait BBS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMK1G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEP170 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RFWD3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat IPR001680 0.52
Category members Znf_RING IPR001841 0
Category members Znf_C3HC4_RING-type IPR018957 0


Protein complexes (CORUM database) featuring RFWD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RFWD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0031571 mitotic G1 DNA damage checkpoint Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0046872 metal ion binding Database 0


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