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Query: RAD21

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAD21 2 6.894 -1.050 0.820 2.113 0.118 0.244 0.668 0.414

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAD21 Ubiquitylation K364 0.738 0.610 _LMMWK(gl)ETGGVEK_
RAD21 Ubiquitylation K72 0.517 _AK(gl)YLLADCNEAFIK_
RAD21 Ubiquitylation K335 -0.110 -0.497 _ELDSK(gl)TIR_
RAD21 Ubiquitylation K387 -0.350 _LLK(gl)LFTR_
RAD21 Ubiquitylation K573 1.907 _ALAK(gl)TGAESISLLELCR_

Background Information for RAD21:


Pubmed-RAD21 »
Uniprot-RAD21 »
Biogrid-RAD21 »
ProteomicsDB-RAD21 »

Tumorportal-RAD21 »
COSMIC-RAD21 »
GenomeRNAi-RAD21 »
Genecards-RAD21


Protein-protein Interactions for RAD21
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAD21 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait WAPAL Cat. description Hein, Mann, Cell 2015
Category members IP bait AARSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMMD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP5K1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUCLA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THBS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR1AIP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAD21
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rad21/Rec8_C_eu IPR006909 0.13
Category members Rad21_Rec8_N IPR006910 0.13


Protein complexes (CORUM database) featuring RAD21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 163 Cohesin-SA2 complex Database 1.44
Category members Corum 166 Cohesin-SA2 complex Database 1.44
Category members Corum 64 Mitotic 14S cohesin 2 complex Database 1.44
Category members Corum 1856 CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex Database 1.25
Category members Corum 5432 Sororin-cohesin complex Database 1.25
Category members Corum 164 Cohesin-SA1 complex Database 0.62
Category members Corum 165 Cohesin-SA1 complex Database 0.62
Category members Corum 63 Mitotic 14S cohesin 1 complex Database 0.62


Categories featuring RAD21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members Disease phenotype Cornelia_de_Lange_syndrome Cornelia de Lange syndrome Database 0.87
Category members GO Category GO:0008278 cohesin complex Database 0.44
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0034991 nuclear meiotic cohesin complex Database 0.11
Category members GO Category GO:0071168 protein localization to chromatin Database 0.04
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0


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