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Query: RAB5B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAB5B 0 1.175 -0.270 0.560 0.223 0.256
RAB5B 0 1.175 -0.270 0.560 0.074 0.374 -1.305

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAB5B Ubiquitylation K174 0.735 _ADLASK(gl)R_
RAB5B Ubiquitylation K116 0.332 0.600 _TWVK(gl)ELQR_
RAB5B Ubiquitylation K150 0.290 0.396 _NWVK(gl)ELQR_
RAB5B Ubiquitylation K168 -0.721 -0.117 _QASPNIVIALAGNK(gl)ADLASK_

Background Information for RAB5B:


Pubmed-RAB5B »
Uniprot-RAB5B »
Biogrid-RAB5B »
ProteomicsDB-RAB5B »

Tumorportal-RAB5B »
COSMIC-RAB5B »
GenomeRNAi-RAB5B »
Genecards-RAB5B


Protein-protein Interactions for RAB5B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GDI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5B Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait FCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAB5B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32


Protein complexes (CORUM database) featuring RAB5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAB5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030100 regulation of endocytosis Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0030742 GTP-dependent protein binding Database 0


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