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Query: PTBP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTBP1 0 5.330 -1.070 1.860 -0.617 -1.830 -1.113

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTBP1 Ubiquitylation K482 1.293 1.265 _VLFSSNGGVVK(gl)GFK_
PTBP1 Ubiquitylation K94 1.069 0.999 _VTNLLMLKGK(gl)_
PTBP1 Phosphorylation S141 0.446 0.650 _ELKTDSS(ph)PNQAR_
PTBP1 Ubiquitylation K92 0.474 0.219 _VTNLLMLK(gl)GK_
PTBP1 Ubiquitylation K13 -0.461 0.072 _(ac)MDGIVPDIAVGTK(gl)R_
PTBP1 Ubiquitylation K137 -0.157 -0.233 _ELK(gl)TDSSPNQAR_
PTBP1 Ubiquitylation K266 0.803 -0.412 _LTSLNVK(gl)YNNDK_
PTBP1 Ubiquitylation K134 0.323 _GQPIYIQFSNHK(gl)ELK_
PTBP1 Phosphorylation T138 0.390 _ELKT(ph)DSSPNQAR_
PTBP1 Phosphorylation S140 0.879 _ELKTDS(ph)SPNQAR_
PTBP1 Ubiquitylation K259 0.361 _IDFSK(gl)LTSLNVK_
PTBP1 Ubiquitylation K410 0.833 _ITLSK(gl)HQNVQLPR_
PTBP1 Ubiquitylation K428 0.281 _EGQEDQGLTK(gl)DYGNSPLHR_
PTBP1 Ubiquitylation K489 0.598 _FFQK(gl)DRK_
PTBP1 Ubiquitylation K528 0.710 _VSFSK(gl)STI_

Background Information for PTBP1:


Pubmed-PTBP1 »
Uniprot-PTBP1 »
Biogrid-PTBP1 »
ProteomicsDB-PTBP1 »

Tumorportal-PTBP1 »
COSMIC-PTBP1 »
GenomeRNAi-PTBP1 »
Genecards-PTBP1


Protein-protein Interactions for PTBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTBP1 Cat. description Hein, Mann, Cell 2015


Protein Domains in PTBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members HnRNP-L_PTB IPR006536 0


Protein complexes (CORUM database) featuring PTBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1288 DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) Database 0


Categories featuring PTBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0048025 negative regulation of mRNA splicing, via spliceosome Database 2.79
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000381 regulation of alternative mRNA splicing, via spliceosome Database 0.5
Category members GO Category GO:0000380 alternative mRNA splicing, via spliceosome Database 0.29
Category members GO Category GO:0008187 poly-pyrimidine tract binding Database 0
Category members GO Category GO:0033119 negative regulation of RNA splicing Database 0
Category members GO Category GO:0036002 pre-mRNA binding Database 0


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