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Query: PRPF6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRPF6 1 6.407 -1.220 1.930 -0.538 -0.333 0.350 0.139 0.304

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRPF6 Ubiquitylation K618 3.222 1.333 _AEVLWLMGAKSK(gl)_
PRPF6 Ubiquitylation K585 0.925 0.567 _AAYFEK(gl)NHGTR_
PRPF6 Ubiquitylation K680 0.476 _VFMK(gl)SVK_
PRPF6 Ubiquitylation K738 -0.238 _EAYNQGLKK(gl)_
PRPF6 Ubiquitylation K146 -2.280 _IQQQFSDLK(gl)R_
PRPF6 Ubiquitylation K737 0.526 _EAYNQGLK(gl)K_

Background Information for PRPF6:


Pubmed-PRPF6 »
Uniprot-PRPF6 »
Biogrid-PRPF6 »
ProteomicsDB-PRPF6 »

Tumorportal-PRPF6 »
COSMIC-PRPF6 »
GenomeRNAi-PRPF6 »
Genecards-PRPF6


Protein-protein Interactions for PRPF6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait PQBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB4B Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WBP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C2orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD2BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1143 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRPF6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members HAT IPR003107 0


Protein complexes (CORUM database) featuring PRPF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring PRPF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0000375 RNA splicing, via transesterification reactions Database 0.73
Category members GO Category GO:0005682 U5 snRNP Database 0.57
Category members GO Category GO:0006403 RNA localization Database 0.49
Category members GO Category GO:0000245 spliceosomal complex assembly Database 0.39
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0000244 spliceosomal tri-snRNP complex assembly Database 0.15
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0046540 U4/U6 x U5 tri-snRNP complex Database 0.01
Category members Disease phenotype Retinitis_pigmentosa Retinitis pigmentosa Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0
Category members GO Category GO:0071001 U4/U6 snRNP Database 0


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