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Query: PRMT5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRMT5 0 0.465 0.330 -0.190 -0.234 0.169
PRMT5 0 0.465 0.330 -0.190 0.437 -0.333 -0.138

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRMT5 Ubiquitylation K200 0.125 0.439 _TLCDYSK(gl)R_
PRMT5 Ubiquitylation K387 0.290 _IK(gl)LYAVEK_
PRMT5 Ubiquitylation K95 0.070 -1.206 _LSPWIRPDSK(gl)VEK_
PRMT5 Ubiquitylation K60 -1.551 -1.863 _EFIQEPAK(gl)NRPGPQTR_
PRMT5 Ubiquitylation K240 -1.218 _AAILPTSIFLTNK(gl)K_
PRMT5 Ubiquitylation K241 -1.002 _AAILPTSIFLTNKK(gl)_

Background Information for PRMT5:


Pubmed-PRMT5 »
Uniprot-PRMT5 »
Biogrid-PRMT5 »
ProteomicsDB-PRMT5 »

Tumorportal-PRMT5 »
COSMIC-PRMT5 »
GenomeRNAi-PRMT5 »
Genecards-PRMT5


Protein-protein Interactions for PRMT5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FBL Cat. description Hein, Mann, Cell 2015
Category members IP bait GAR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYEF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait PRMT5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CIRBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FARP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSM6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBFOX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBFOX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFPQ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINAGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRMT5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members Arg_MeTrfase IPR025799 0


Protein complexes (CORUM database) featuring PRMT5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 710 Brg1-associated complex I Database 1.57
Category members Corum 711 Brm-associated complex Database 1.57
Category members Corum 808 BRM-associated complex Database 1.57
Category members Corum 807 BRG1-associated complex Database 1.16
Category members Corum 3063 Brg1-associated complex II Database 0.62
Category members Corum 810 FCP1-associated protein complex Database 0.1
Category members Corum 811 FCP1-associated protein complex Database 0.1
Category members Corum 2838 AR coactivator complex Database 0.06
Category members Corum 837 20S methyltransferase complex Database 0.06
Category members Corum 1231 FIB-associated protein complex Database 0
Category members Corum 819 20S methylosome-SmD complex Database 0
Category members Corum 825 JBP1-pICln complex Database 0
Category members Corum 832 Anti-Sm protein complex Database 0
Category members Corum 834 20S methylosome and RG-containing Sm protein complex Database 0
Category members Corum 836 20S methyltransferase core complex Database 0


Categories featuring PRMT5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_887 REACTOME_METABOLISM_OF_NON_CODING_RNA 0 4.38
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0018216 peptidyl-arginine methylation Database 0.1
Category members GO Category GO:0007088 regulation of mitosis Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0008469 histone-arginine N-methyltransferase activity Database 0.05
Category members GO Category GO:0000387 spliceosomal snRNP assembly Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0006479 protein methylation Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine Database 0
Category members GO Category GO:0034660 ncRNA metabolic process Database 0
Category members GO Category GO:0035243 protein-arginine omega-N symmetric methyltransferase activity Database 0
Category members GO Category GO:0035246 peptidyl-arginine N-methylation Database 0
Category members GO Category GO:0042118 endothelial cell activation Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0
Category members GO Category GO:0043985 histone H4-R3 methylation Database 0


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