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Query: PPP2R2A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP2R2A 0 0.412 1.330 -0.870 -0.611 -0.009 -0.066 -0.157 -0.064

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP2R2A Ubiquitylation K62 1.437 -0.118 _VVIFQQEQENK(gl)IQSHSR_

Background Information for PPP2R2A:


Pubmed-PPP2R2A »
Uniprot-PPP2R2A »
Biogrid-PPP2R2A »
ProteomicsDB-PPP2R2A »

Tumorportal-PPP2R2A »
COSMIC-PPP2R2A »
GenomeRNAi-PPP2R2A »
Genecards-PPP2R2A


Protein-protein Interactions for PPP2R2A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRNKL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERP44 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2D Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait VANGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2CB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERTAD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP2R2A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members PP2A_PR55 IPR000009 0


Protein complexes (CORUM database) featuring PPP2R2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5211 RAF1-PPP2-PIN1 complex Database 0


Categories featuring PPP2R2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0007084 mitotic nuclear envelope reassembly Database 0.24
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0000159 protein phosphatase type 2A complex Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008601 protein phosphatase type 2A regulator activity Database 0
Category members GO Category GO:0043278 response to morphine Database 0


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