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Query: PPIE

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPIE 2 8.130 -2.470 3.680 2.485 0.018 1.294 0.696
PPIE 2 8.130 -2.470 3.680 0.176 -1.635 -1.146

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPIE Ubiquitylation K190 -0.831 _KIESFGSK(gl)SGR_
PPIE Ubiquitylation K83 -0.219 _VNLAK(gl)PMR_

Background Information for PPIE:


Pubmed-PPIE »
Uniprot-PPIE »
Biogrid-PPIE »
ProteomicsDB-PPIE »

Tumorportal-PPIE »
COSMIC-PPIE »
GenomeRNAi-PPIE »
Genecards-PPIE


Protein-protein Interactions for PPIE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC12 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRNKL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ISY1;RAB43 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNW1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DVL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1143 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPIE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALYL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC10A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC19A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPIE
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members Cyclophilin-type_PPIase_dom IPR002130 0.54
Category members Cyclophilin-like_dom IPR029000 0.54


Protein complexes (CORUM database) featuring PPIE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring PPIE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0003755 peptidyl-prolyl cis-trans isomerase activity Database 1.31
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0016018 cyclosporin A binding Database 0.28
Category members GO Category GO:0000413 protein peptidyl-prolyl isomerization Database 0.25
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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