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Query: PPIA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPIA 2 3.210 4.080 -1.410 0.241 1.212 -1.216 0.426 -0.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPIA Ubiquitylation K82 0.354 2.128 _SIYGEK(gl)FEDENFILK_
PPIA Ubiquitylation K44 0.553 0.832 _ALSTGEK(gl)GFGYK_
PPIA Ubiquitylation K49 0.505 0.774 _GFGYK(gl)GSCFHR_
PPIA Ubiquitylation K125 0.268 0.377 _TEWLDGK(gl)HVVFGK_
PPIA Ubiquitylation K133 0.034 0.019 _VK(gl)EGMNIVEAMER_
PPIA Ubiquitylation K131 0.609 -0.067 _HVVFGK(gl)VK_
PPIA Ubiquitylation K28 0.396 _VSFELFADK(gl)VPK_
PPIA Ubiquitylation K155 0.233 _K(gl)ITIADCGQLE_

Background Information for PPIA:


Pubmed-PPIA »
Uniprot-PPIA »
Biogrid-PPIA »
ProteomicsDB-PPIA »

Tumorportal-PPIA »
COSMIC-PPIA »
GenomeRNAi-PPIA »
Genecards-PPIA


Protein-protein Interactions for PPIA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CSDE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPIA Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015


Protein Domains in PPIA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclophilin-type_PPIase_dom IPR002130 0.54
Category members Cyclophilin-like_dom IPR029000 0.54


Protein complexes (CORUM database) featuring PPIA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5843 AIF-CYPA-DNA complex Database 0.32


Categories featuring PPIA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0003755 peptidyl-prolyl cis-trans isomerase activity Database 1.31
Category members Pathway Pathway_981 REACTOME_INTEGRATION_OF_PROVIRUS 0 0.76
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_1215 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION 0 0.32
Category members GO Category GO:0030260 entry into host cell Database 0.32
Category members GO Category GO:0034389 lipid particle organization Database 0.28
Category members GO Category GO:0000413 protein peptidyl-prolyl isomerization Database 0.25
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0045069 regulation of viral genome replication Database 0.05
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_927 REACTOME_BASIGIN_INTERACTIONS 0 0
Category members Pathway Pathway_1313 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0006278 RNA-dependent DNA replication Database 0
Category members GO Category GO:0019068 virion assembly Database 0
Category members GO Category GO:0019076 viral release from host cell Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0046790 virion binding Database 0
Category members GO Category GO:0050714 positive regulation of protein secretion Database 0


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