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Query: POT1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POT1 0 -1.327 0.280 -0.550

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POT1 Ubiquitylation K469 -1.327 _LSNK(gl)FNSVIPVR_

Background Information for POT1:


Pubmed-POT1 »
Uniprot-POT1 »
Biogrid-POT1 »
ProteomicsDB-POT1 »

Tumorportal-POT1 »
COSMIC-POT1 »
GenomeRNAi-POT1 »
Genecards-POT1


Protein-protein Interactions for POT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait ID1 Cat. description Hein, Mann, Cell 2015
Category members IP bait POT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF2IP Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TERF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37


Protein complexes (CORUM database) featuring POT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1204 Rap1 complex Database 0.04
Category members Corum 1197 TRF1-TIN2 complex Database 0
Category members Corum 1198 TIN2 complex Database 0
Category members Corum 1201 TRF1-TIN2 complex Database 0
Category members Corum 1206 TRF-Rap1 complex I, 2MD Database 0
Category members Corum 1207 TRF2-Rap1 complex II Database 0
Category members Corum 138 Telosome complex Database 0


Categories featuring POT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0051096 positive regulation of helicase activity Database 0.73
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members GO Category GO:0017151 DEAD/H-box RNA helicase binding Database 0.1
Category members GO Category GO:0010521 telomerase inhibitor activity Database 0.08
Category members GO Category GO:0032212 positive regulation of telomere maintenance via telomerase Database 0.02
Category members Disease phenotype B-cell_chronic_lymphocytic_leukemia B-cell chronic lymphocytic leukemia Database 0.01
Category members Disease phenotype Familial_melanoma Familial melanoma Database 0
Category members GO Category GO:0016233 telomere capping Database 0
Category members GO Category GO:0032203 telomere formation via telomerase Database 0
Category members GO Category GO:0032211 negative regulation of telomere maintenance via telomerase Database 0
Category members GO Category GO:0043047 single-stranded telomeric DNA binding Database 0
Category members GO Category GO:0051973 positive regulation of telomerase activity Database 0
Category members GO Category GO:0051974 negative regulation of telomerase activity Database 0


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