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Query: POLR3A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLR3A 1 5.072 -0.550 1.310 -0.221 0.400 0.226

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLR3A Ubiquitylation K398 0.278 _VNK(gl)ANINFLR_
POLR3A Ubiquitylation K439 -0.169 _EK(gl)MAQELK_
POLR3A Ubiquitylation K1242 0.246 -0.360 _AVM(ox)ATHGVK(gl)GTR_
POLR3A Ubiquitylation K713 -2.239 _AK(gl)YELLNAGYK_
POLR3A Ubiquitylation K974 3.079 _FIK(gl)GVSEK_

Background Information for POLR3A:


Pubmed-POLR3A »
Uniprot-POLR3A »
Biogrid-POLR3A »
ProteomicsDB-POLR3A »

Tumorportal-POLR3A »
COSMIC-POLR3A »
GenomeRNAi-POLR3A »
Genecards-POLR3A


Protein-protein Interactions for POLR3A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR3E Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCZ Cat. description Hein, Mann, Cell 2015
Category members IP bait ZW10 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C21orf63 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3GL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUVBL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUVBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLR3A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNA_pol_asu IPR000722 0.68
Category members RNA_pol_N IPR006592 0.68
Category members RNA_pol_Rpb1_3 IPR007066 0.68
Category members RNA_pol_Rpb1_1 IPR007080 0.68
Category members RNA_pol_Rpb1_5 IPR007081 0.68
Category members RNA_pol_Rpb1_4 IPR007083 0.68


Protein complexes (CORUM database) featuring POLR3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring POLR3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032549 ribonucleoside binding Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0001056 RNA polymerase III activity Database 1.02
Category members Pathway Pathway_349 KEGG_RNA_POLYMERASE 0 0.91
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0003899 DNA-directed RNA polymerase activity Database 0.46
Category members Pathway Pathway_355 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER 0 0.37
Category members Pathway Pathway_353 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION 0 0.29
Category members Pathway Pathway_357 REACTOME_RNA_POL_III_TRANSCRIPTION 0 0.29
Category members GO Category GO:0005666 DNA-directed RNA polymerase III complex Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Disease phenotype Hypomyelination_-_hypogonadotropic_hypogonadism_-_hypodontia Hypomyelination - hypogonadotropic hypogonadism - hypodontia Database 0.28
Category members Pathway Pathway_356 REACTOME_RNA_POL_III_CHAIN_ELONGATION 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0006383 transcription from RNA polymerase III promoter Database 0.18
Category members GO Category GO:0006385 transcription elongation from RNA polymerase III promoter Database 0.18
Category members GO Category GO:0006386 termination of RNA polymerase III transcription Database 0.18
Category members Pathway Pathway_352 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER 0 0.11
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members GO Category GO:0032728 positive regulation of interferon-beta production Database 0


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