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Query: POLR2B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLR2B 2 5.336 -0.420 0.060
POLR2B 2 5.336 -0.420 0.060 -0.204 1.234 2.104 -1.532 0.478

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLR2B Ubiquitylation K43 0.529 _TVIK(gl)EGEEQLQTQHQK_
POLR2B Ubiquitylation K55 1.247 0.522 _EGEEQLQTQHQK(gl)TFIGK_
POLR2B Ubiquitylation K123 0.490 _DSK(gl)YAYTGECR_
POLR2B Ubiquitylation K120 0.324 _K(gl)DSKYAYTGECR_
POLR2B Ubiquitylation K367 2.667 0.205 _YSLATGNWGDQKK(gl)_
POLR2B Ubiquitylation K366 2.033 0.015 _YSLATGNWGDQK(gl)K_
POLR2B Ubiquitylation K539 -0.182 -0.025 _ICRPLLIVEK(gl)QK_
POLR2B Ubiquitylation K541 -0.374 -0.025 _ICRPLLIVEK(gl)QK_
POLR2B Ubiquitylation K60 -0.347 _TFIGK(gl)IPIMLR_
POLR2B Ubiquitylation K270 -0.350 _EMLPHVGVSDFCETKK(gl)_
POLR2B Ubiquitylation K740 -0.513 _GFDQEEVFEK(gl)PTR_
POLR2B Ubiquitylation K1052 -0.541 _NK(gl)TQISLVR_
POLR2B Ubiquitylation K843 0.603 -0.748 _IPQIGDK(gl)FASR_
POLR2B Ubiquitylation K902 0.615 -0.938 _VSANK(gl)GEIGDATPFNDAVNVQK_
POLR2B Ubiquitylation K157 1.882 _GGQGAK(gl)K(gl)SAIGQR_
POLR2B Ubiquitylation K158 1.882 _GGQGAK(gl)K(gl)SAIGQR_
POLR2B Ubiquitylation K249 0.973 _YAK(gl)EVLQK_
POLR2B Ubiquitylation K665 -0.055 _MDTLAHVLYYPQK(gl)PLVTTR_
POLR2B Ubiquitylation K851 0.621 _HGQK(gl)GTCGIQYR_

Background Information for POLR2B:


Pubmed-POLR2B »
Uniprot-POLR2B »
Biogrid-POLR2B »
ProteomicsDB-POLR2B »

Tumorportal-POLR2B »
COSMIC-POLR2B »
GenomeRNAi-POLR2B »
Genecards-POLR2B


Protein-protein Interactions for POLR2B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRD2;DKFZp313H139 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2B Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait WHSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRINL1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPRD1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLR2B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_RNA_pol_su2_6 IPR007120 0.68
Category members RNA_pol_Rpb2_7 IPR007641 0.68
Category members RNA_pol_Rpb2_2 IPR007642 0.68
Category members RNA_pol_bsu_protrusion IPR007644 0.68
Category members RNA_pol_Rpb2_3 IPR007645 0.68
Category members RNA_pol_Rpb2_5 IPR007647 0.68
Category members RNA_pol_Rpb2_4 IPR007646 0.28


Protein complexes (CORUM database) featuring POLR2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1155 Integrator-RNAPII complex Database 5.97
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 103 RNA polymerase II holoenzyme complex Database 1.07
Category members Corum 2686 BRCA1-core RNA polymerase II complex Database 0.51
Category members Corum 1254 Menin-associated histone methyltransferase complex Database 0.35
Category members Corum 104 RNA polymerase II core complex Database 0.29
Category members Corum 2685 RNA polymerase II (RNAPII) Database 0.12
Category members Corum 810 FCP1-associated protein complex Database 0.1
Category members Corum 811 FCP1-associated protein complex Database 0.1
Category members Corum 2812 RPAP1-RPB2-RPB3 complex Database 0


Categories featuring POLR2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_369 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 0 INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members GO Category GO:0032549 ribonucleoside binding Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_349 KEGG_RNA_POLYMERASE 0 0.91
Category members GO Category GO:0001055 RNA polymerase II activity Database 0.54
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0003899 DNA-directed RNA polymerase activity Database 0.46
Category members GO Category GO:0005665 DNA-directed RNA polymerase II, core complex Database 0.38
Category members Pathway Pathway_364 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT 0 0.35
Category members Pathway Pathway_370 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 0 0.34
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_368 REACTOME_MICRORNA_MIRNA_BIOGENESIS 0 0.18
Category members Pathway Pathway_358 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS 0 0.14
Category members Pathway Pathway_379 REACTOME_REGULATORY_RNA_PATHWAYS 0 0.12
Category members GO Category GO:0046872 metal ion binding Database 0


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