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Query: POLH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLH 0 -1.696

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLH Ubiquitylation K70 -0.166 _SMWADDAKK(gl)_
POLH Ubiquitylation K328 -0.315 _NFPGK(gl)TALATR_
POLH Ubiquitylation K91 -0.322 _ANLTK(gl)YR_
POLH Ubiquitylation K682 -1.530 -1.226 _SFLQPHSSNPQVVSAVSHQGK(gl)R_

Background Information for POLH:


Pubmed-POLH »
Uniprot-POLH »
Biogrid-POLH »
ProteomicsDB-POLH »

Tumorportal-POLH »
COSMIC-POLH »
GenomeRNAi-POLH »
Genecards-POLH


Protein-protein Interactions for POLH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait POLH Cat. description Hein, Mann, Cell 2015
Category members IP bait LSM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLH
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA_repair_prot_UmuC-like IPR001126 0
Category members DNA_pol_Y-fam_little_finger IPR017961 0
Category members DNA_repair_prot_UmuC-like_N IPR017963 0


Protein complexes (CORUM database) featuring POLH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3070 CTF18-cohesion-RFC-POLH complex Database 0.17


Categories featuring POLH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0006290 pyrimidine dimer repair Database 0.25
Category members GO Category GO:0000731 DNA synthesis involved in DNA repair Database 0
Category members GO Category GO:0003887 DNA-directed DNA polymerase activity Database 0
Category members GO Category GO:0006282 regulation of DNA repair Database 0
Category members GO Category GO:0006301 postreplication repair Database 0
Category members GO Category GO:0010225 response to UV-C Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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