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Query: PKLR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PKLR 0 2.690 1.140 -1.050 0.017 1.398 -1.294 0.074 -0.041

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PKLR Ubiquitylation K498 -0.348 1.499 _VNFAMNVGK(gl)AR_
PKLR Ubiquitylation K66 0.692 1.175 _EMIK(gl)SGMNVAR_
PKLR Ubiquitylation K136 1.129 _GSGTAEVELKK(gl)_
PKLR Ubiquitylation K207 0.653 1.108 _GADFLVTEVENGGSLGSKK(gl)_
PKLR Ubiquitylation K206 0.325 0.965 _GADFLVTEVENGGSLGSK(gl)K_
PKLR Ubiquitylation K166 0.555 0.929 _NICK(gl)VVEVGSK_
PKLR Ubiquitylation K322 0.128 0.502 _AGK(gl)PVICATQMLESMIK_
PKLR Ubiquitylation K433 0.399 _CCSGAIIVLTK(gl)SGR_
PKLR Ubiquitylation K62 0.782 0.248 _SVETLK(gl)EMIK_
PKLR Ubiquitylation K311 0.807 0.083 _VFLAQK(gl)MMIGR_
PKLR Phosphorylation S37 -0.098 0.015 _LDIDS(ph)PPITAR_
PKLR Ubiquitylation K305 -0.028 -0.012 _GDLGIEIPAEK(gl)VFLAQK_
PKLR Ubiquitylation K270 0.863 -0.154 _IISK(gl)IENHEGVR_
PKLR Ubiquitylation K266 1.003 -0.378 _GKNIK(gl)IISK_
PKLR Ubiquitylation K135 0.397 _GSGTAEVELK(gl)K_
PKLR Ubiquitylation K141 1.121 _GATLK(gl)ITLDNAYMEK_

Background Information for PKLR:


Pubmed-PKLR »
Uniprot-PKLR »
Biogrid-PKLR »
ProteomicsDB-PKLR »

Tumorportal-PKLR »
COSMIC-PKLR »
GenomeRNAi-PKLR »
Genecards-PKLR


Protein-protein Interactions for PKLR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP4B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5DC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PKLR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pyr_Knase IPR001697 0.22
Category members Pyrv_Knase_brl IPR015793 0.22
Category members Pyrv_Knase_C IPR015795 0.22
Category members Pyrv_Knase-like_insert_dom IPR011037 0.21
Category members Pyrv/PenolPyrv_Kinase-like_dom IPR015813 0.03


Protein complexes (CORUM database) featuring PKLR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PKLR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_59 BIOCARTA_GLYCOLYSIS_PATHWAY 0 1.96
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0004743 pyruvate kinase activity Database 0.22
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_121 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 0 0.18
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0033198 response to ATP Database 0.04
Category members GO Category GO:0031325 positive regulation of cellular metabolic process Database 0.04
Category members Pathway Pathway_122 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 0 0.01
Category members Pathway Pathway_124 KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0006754 ATP biosynthetic process Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0010226 response to lithium ion Database 0
Category members GO Category GO:0030955 potassium ion binding Database 0
Category members GO Category GO:0031018 endocrine pancreas development Database 0
Category members GO Category GO:0042866 pyruvate biosynthetic process Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0051707 response to other organism Database 0


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