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Query: PDHA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDHA1 1 5.563 -0.760 1.860
PDHA1 1 5.563 -0.760 1.860 0.830 -0.675 -1.114 0.710 0.474
PDHA1 1 5.563 0.410 -0.200
PDHA1 1 5.563 0.410 -0.200 0.830 -0.675 -1.114 0.710 0.474

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDHA1 Phosphorylation T231 1.539 1.081 _YGMGT(ph)SVER_
PDHA1 Phosphorylation S293 0.346 0.996 _YHGHS(ph)M(ox)SDPGVSYR_
PDHA1 Phosphorylation S232 1.452 0.823 _YGM(ox)GTS(ph)VER_
PDHA1 Phosphorylation S295 0.274 0.755 _YHGHSMS(ph)DPGVSYR_
PDHA1 Ubiquitylation K244 -0.931 _AAASTDYYK(gl)R_

Background Information for PDHA1:


Pubmed-PDHA1 »
Uniprot-PDHA1 »
Biogrid-PDHA1 »
ProteomicsDB-PDHA1 »

Tumorportal-PDHA1 »
COSMIC-PDHA1 »
GenomeRNAi-PDHA1 »
Genecards-PDHA1


Protein-protein Interactions for PDHA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait STAT5A Cat. description Hein, Mann, Cell 2015
Category members IP bait STAT5B Cat. description Hein, Mann, Cell 2015
Category members IP bait DLD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAT5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDHA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DH_E1 IPR001017 0.19
Category members Pyrv_DH_E1_asu_subgrp-y IPR017597 0.09
Category members THDP-binding IPR029061 0.04


Protein complexes (CORUM database) featuring PDHA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDHA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Database 0.19
Category members Pathway Pathway_47 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0 0.09
Category members Disease phenotype Leigh_syndrome_with_cardiomyopathy Leigh syndrome with cardiomyopathy Database 0.09
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity Database 0.07
Category members GO Category GO:0045254 pyruvate dehydrogenase complex Database 0.07
Category members Pathway Pathway_14 REACTOME_PYRUVATE_METABOLISM 0 0.05
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members Pathway Pathway_15 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 0 0
Category members Pathway Pathway_46 KEGG_BUTANOATE_METABOLISM 0 0
Category members GO Category GO:0004738 pyruvate dehydrogenase activity Database 0
Category members GO Category GO:0006086 acetyl-CoA biosynthetic process from pyruvate Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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