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Query: PBRM1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PBRM1 1 3.665 1.130 -0.860 0.203 -0.319 0.305 0.606 0.462

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PBRM1 Phosphorylation S39 1.987 0.805 _RLS(ph)NLPTVDPIAVCHELYNTIR_
PBRM1 Phosphorylation S178 0.199 0.037 _GEADDEDDDEDGQDNQGTVTEGSS(ph)PAYLK_
PBRM1 Phosphorylation S10 -0.217 -0.034 _ATS(ph)PSSSVSGDFDDGHHSVSTPGPSR_
PBRM1 Ubiquitylation K1642 0.436 -0.821 _DVHLSK(gl)EQESR_
PBRM1 Phosphorylation S636 -1.172 _ELGPLPDDDDM(ox)AS(ph)PK_
PBRM1 Phosphorylation T9 -0.114 _AT(ph)SPSSSVSGDFDDGHHSVSTPGPSR_
PBRM1 Phosphorylation S14 0.006 _ATSPSSS(ph)VSGDFDDGHHSVSTPGPSR_
PBRM1 Phosphorylation S177 0.200 _GEADDEDDDEDGQDNQGTVTEGS(ph)SPAYLK_
PBRM1 Ubiquitylation K1019 -0.114 _EVFK(gl)SDYYNKVPVSK_
PBRM1 Ubiquitylation K1293 -1.845 _K(gl)PIVPQKEPSPLLEK_
PBRM1 Ubiquitylation K1398 -0.220 _AVIK(gl)AQHPDYSFGELSR_

Background Information for PBRM1:


Pubmed-PBRM1 »
Uniprot-PBRM1 »
Biogrid-PBRM1 »
ProteomicsDB-PBRM1 »

Tumorportal-PBRM1 »
COSMIC-PBRM1 »
GenomeRNAi-PBRM1 »
Genecards-PBRM1


Protein-protein Interactions for PBRM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PBRM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Bromodomain IPR001487 1.43
Category members BAH_dom IPR001025 0.62
Category members HMG_box_dom IPR009071 0.31


Protein complexes (CORUM database) featuring PBRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 554 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 565 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 149 PBAF complex (Polybromo- and BAF containing complex) Database 1.36
Category members Corum 1238 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 556 PBAF complex (Polybromo- and BAF containing complex) Database 1.16


Categories featuring PBRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Disease phenotype RENAL_CELL_CARCINOMA_NONPAPILLARY RENAL CELL CARCINOMA NONPAPILLARY Database 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007507 heart development Database 0


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