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Query: NXF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NXF1 0 0.404 -0.262 0.366 0.002

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NXF1 Ubiquitylation K173 0.298 _AQFFVEDASTASALK(gl)AVNYK_
NXF1 Ubiquitylation K607 0.028 _SAQAFTHLK(gl)AK_

Background Information for NXF1:


Pubmed-NXF1 »
Uniprot-NXF1 »
Biogrid-NXF1 »
ProteomicsDB-NXF1 »

Tumorportal-NXF1 »
COSMIC-NXF1 »
GenomeRNAi-NXF1 »
Genecards-NXF1


Protein-protein Interactions for NXF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEH1L Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait GPR37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NXF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Leu-rich_rpt IPR001611 0.32
Category members UBA-like IPR009060 0.17
Category members NTF2 IPR002075 0
Category members Tap_RNA-bd IPR015245 0
Category members Nuclear_transport_factor_2_euk IPR018222 0


Protein complexes (CORUM database) featuring NXF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 814 Postsplicing complex Database 0.01
Category members Corum 1552 TNPO2-RAN-NXF1 complex Database 0


Categories featuring NXF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0000346 transcription export complex Database 1.18
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members GO Category GO:0005487 nucleocytoplasmic transporter activity Database 0.79
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006405 RNA export from nucleus Database 0.24
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0016973 poly(A)+ mRNA export from nucleus Database 0


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