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Query: NUP214

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NUP214 1 3.308 2.360 -1.290 0.632 0.242 0.147

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NUP214 Phosphorylation S646 1.342 0.945 _SSVLPS(ph)PSGR_
NUP214 Phosphorylation S657 0.933 0.690 _SAQGSSS(ph)PVPSMVQK_
NUP214 Phosphorylation S940 0.199 0.044 _VPAKLS(ph)PMK_
NUP214 Phosphorylation S678 -0.473 -0.254 _ITPPAAKPGS(ph)PQAK_
NUP214 Phosphorylation T439 -0.425 _SPGS(ph)TPTTPT(ph)SSQAPQK_
NUP214 Phosphorylation T437 0.179 -0.458 _SPGS(ph)TPTT(ph)PTSSQAPQK_
NUP214 Phosphorylation S1023 -0.863 -0.765 _TPS(ph)IQPSLLPHAAPFAK_
NUP214 Phosphorylation T436 -0.669 -0.832 _SPGS(ph)TPT(ph)TPTSSQAPQK_
NUP214 Phosphorylation S433 -0.565 -1.014 _SPGS(ph)TPTT(ph)PTSSQAPQK_
NUP214 Phosphorylation S1081 -1.320 -1.047 _HGAPS(ph)PSHPISAPQAAAAAALR_
NUP214 Phosphorylation S430 -1.401 -1.571 _S(ph)PGSTPTTPTSSQAPQK_

Background Information for NUP214:


Pubmed-NUP214 »
Uniprot-NUP214 »
Biogrid-NUP214 »
ProteomicsDB-NUP214 »

Tumorportal-NUP214 »
COSMIC-NUP214 »
GenomeRNAi-NUP214 »
Genecards-NUP214


Protein-protein Interactions for NUP214
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP155 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP188 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP214 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEH1L Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait DDX19A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EMILIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait G3BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NUP214
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring NUP214
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NUP214
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Pathway Pathway_1310 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 0 7.24
Category members Pathway Pathway_1311 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 0 7.24
Category members Pathway Pathway_1206 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 0 6.87
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0010827 regulation of glucose transport Database 5.83
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members Pathway Pathway_120 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_887 REACTOME_METABOLISM_OF_NON_CODING_RNA 0 4.38
Category members GO Category GO:0008645 hexose transport Database 4.15
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members Pathway Pathway_98 REACTOME_GLUCOSE_TRANSPORT 0 3.58
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0015758 glucose transport Database 2.09
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0005487 nucleocytoplasmic transporter activity Database 0.79
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0


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