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Query: NSUN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NSUN2 1 4.668 -0.630 0.380 0.495 -0.365
NSUN2 1 4.668 -0.630 0.380 -0.793 -0.402 -0.165

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NSUN2 Phosphorylation S593 1.207 1.722 _NNS(ph)GEEFDCAFR_
NSUN2 Ubiquitylation K565 1.464 _QLYMVSK(gl)ELR_
NSUN2 Ubiquitylation K95 0.374 _EILHCLK(gl)NK_
NSUN2 Phosphorylation T453 0.154 0.148 _EST(ph)QLSPADLTEGKPTDPSK_
NSUN2 Phosphorylation S456 0.187 0.131 _ESTQLS(ph)PADLTEGKPTDPSK_
NSUN2 Ubiquitylation K654 0.538 -0.353 _DLAK(gl)GSIVLK_
NSUN2 Ubiquitylation K579 1.054 -0.390 _MK(gl)VINTGIK_
NSUN2 Ubiquitylation K286 0.469 -0.479 _NIDVWKK(gl)_
NSUN2 Ubiquitylation K640 0.276 -0.635 _K(gl)LSSETYSQAK_
NSUN2 Ubiquitylation K650 0.357 -0.742 _KLSSETYSQAK(gl)DLAK_
NSUN2 Ubiquitylation K437 -0.886 _SSMPWNK(gl)R_
NSUN2 Phosphorylation S751 -0.991 -1.534 _AGEPNSPDAEEANS(ph)PDVTAGCDPAGVHPPR_
NSUN2 Phosphorylation S743 -1.676 -1.545 _AGEPNS(ph)PDAEEANS(ph)PDVTAGCDPAGVHPPR_
NSUN2 Ubiquitylation K229 1.125 _CYLLVHQAK(gl)R_
NSUN2 Ubiquitylation K577 0.039 _NVLLNNSEK(gl)MK_

Background Information for NSUN2:


Pubmed-NSUN2 »
Uniprot-NSUN2 »
Biogrid-NSUN2 »
ProteomicsDB-NSUN2 »

Tumorportal-NSUN2 »
COSMIC-NSUN2 »
GenomeRNAi-NSUN2 »
Genecards-NSUN2


Protein-protein Interactions for NSUN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR20E Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NSUN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members Fmu/NOL1/Nop2p IPR001678 0.04
Category members RCMT IPR023267 0.03


Protein complexes (CORUM database) featuring NSUN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NSUN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0005819 spindle Database 0.41
Category members Disease phenotype Autosomal_recessive_non-syndromic_intellectual_disability Autosomal recessive non-syndromic intellectual disability Database 0
Category members GO Category GO:0000049 tRNA binding Database 0
Category members GO Category GO:0030488 tRNA methylation Database 0


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