bioLOGIC-db

bioLOGIC Data

Query: NHP2L1

This is a cancer-associated gene according to the Sanger cancer gene census.

[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
NHP2L1	0	1.754			-0.100	-0.558		0.469	0.546

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
NHP2L1	Ubiquitylation	K37	0.517	0.880	_LLDLVQQSCNYK(gl)QLR_
NHP2L1	Ubiquitylation	K24		0.135	_AYPLADAHLTK(gl)K_
NHP2L1	Ubiquitylation	K41	-0.526	-0.216	_K(gl)GANEATK(gl)TLNR_
NHP2L1	Ubiquitylation	K25	0.099	-0.243	_AYPLADAHLTKK(gl)_
NHP2L1	Ubiquitylation	K48	-0.393	-0.294	_K(gl)GANEATK(gl)TLNR_
NHP2L1	Ubiquitylation	K13	-1.011	-1.424	_(ac)TEADVNPK(gl)AYPLADAHLTK_
NHP2L1	Ubiquitylation	K117	-0.068		_EGSQLK(gl)QQIQSIQQSIER_

ProteomicsDB-NHP2L1 »

Protein-protein Interactions for NHP2L1

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait PRPF3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PRPF4	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait LSM5	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PRPF3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PRPF4	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SNRPN	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in NHP2L1

Protein complexes (CORUM database) featuring NHP2L1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	3055	Nop56p-associated pre-rRNA complex	Database	INF
Category members	Corum	351	Spliceosome	Database	9.3

Categories featuring NHP2L1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0003723	RNA binding	Database	INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0010467	gene expression	Database	INF
Category members	GO Category	GO:0005730	nucleolus	Database	13.38
Category members	Pathway	Pathway_373	REACTOME_MRNA_PROCESSING	0	12.92
Category members	Pathway	Pathway_380	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	0	12.24
Category members	GO Category	GO:0008380	RNA splicing	Database	10.77
Category members	GO Category	GO:0030529	ribonucleoprotein complex	Database	8.45
Category members	Pathway	Pathway_851	KEGG_SPLICEOSOME	0	7.94
Category members	GO Category	GO:0000398	mRNA splicing, via spliceosome	Database	7.06
Category members	Pathway	Pathway_377	REACTOME_MRNA_SPLICING	0	6.99
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	GO Category	GO:0005681	spliceosomal complex	Database	3.88
Category members	DDR Literature	pubmedid:19647519	Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation		3.6
Category members	Pathway	Pathway_372	REACTOME_MRNA_SPLICING_MINOR_PATHWAY	0	1.52
Category members	GO Category	GO:0031428	box C/D snoRNP complex	Database	0.79
Category members	GO Category	GO:0042254	ribosome biogenesis	Database	0.29
Category members	GO Category	GO:0030515	snoRNA binding	Database	0.07