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Query: NEK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEK1 1 4.458 -1.440 3.230

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEK1 Phosphorylation S1126 0.472 0.693 _EQPGEEYS(ph)EEEESVLK_
NEK1 Phosphorylation S1052 0.195 0.324 _TCS(ph)LPDLSK_
NEK1 Phosphorylation S664 0.535 _SSDVSPPLGQHETGGS(ph)PSK_

Background Information for NEK1:


Pubmed-NEK1 »
Uniprot-NEK1 »
Biogrid-NEK1 »
ProteomicsDB-NEK1 »

Tumorportal-NEK1 »
COSMIC-NEK1 »
GenomeRNAi-NEK1 »
Genecards-NEK1


Protein-protein Interactions for NEK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP104 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMK2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTDSP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEKT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS26B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring NEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members Disease phenotype Short_rib-polydactyly_syndrome_Majewski_type Short rib-polydactyly syndrome Majewski type Database 0
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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