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Query: NDRG1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NDRG1 0 2.653 -1.240 1.600
NDRG1 0 2.653 -1.240 1.600 -0.614 1.252 0.551

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NDRG1 Phosphorylation S2 0.483 0.404 _(ac)S(ph)REMQDVDLAEVKPLVEK_
NDRG1 Phosphorylation S326 0.379 _S(ph)RTAS(ph)GSSVTSLDGTR_
NDRG1 Phosphorylation T328 0.330 0.373 _SRT(ph)ASGSSVTSLDGTR_
NDRG1 Phosphorylation S330 0.313 -0.175 _TAS(ph)GSSVTSLDGTR_
NDRG1 Phosphorylation S333 -0.356 -0.210 _TAS(ph)GSS(ph)VTSLDGTR_
NDRG1 Phosphorylation T366 -0.144 -0.451 _SHT(ph)SEGAHLDITPNSGAAGNSAGPK_
NDRG1 Phosphorylation S364 -0.164 -0.457 _S(ph)HTSEGAHLDITPNSGAAGNSAGPK_
NDRG1 Ubiquitylation K300 -0.507 -0.742 _MADCGGLPQISQPAK(gl)LAEAFK_
NDRG1 Phosphorylation T335 0.708 -0.841 _TAS(ph)GSSVT(ph)SLDGTR_
NDRG1 Phosphorylation S336 -0.491 -1.009 _TAS(ph)GSSVTS(ph)LDGTR_
NDRG1 Phosphorylation T375 -1.996 -1.540 _SHTSEGAHLDIT(ph)PNSGAAGNSAGPK_
NDRG1 Ubiquitylation K285 -2.380 _TTLLK(gl)MADCGGLPQISQPAK_
NDRG1 Phosphorylation S332 0.247 _TASGS(ph)SVTSLDGTR_
NDRG1 Phosphorylation S367 -0.333 _SHTS(ph)EGAHLDITPNSGAAGNSAGPK_
NDRG1 Ubiquitylation K14 -1.017 _EMQDVDLAEVK(gl)PLVEK_

Background Information for NDRG1:


Pubmed-NDRG1 »
Uniprot-NDRG1 »
Biogrid-NDRG1 »
ProteomicsDB-NDRG1 »

Tumorportal-NDRG1 »
COSMIC-NDRG1 »
GenomeRNAi-NDRG1 »
Genecards-NDRG1


Protein-protein Interactions for NDRG1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM60A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FXYD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDE4DIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait S1PR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NDRG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AB_hydrolase_1 IPR000073 0
Category members NDRG IPR004142 0
Category members AB_hydrolase IPR029058 0


Protein complexes (CORUM database) featuring NDRG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NDRG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0032287 peripheral nervous system myelin maintenance Database 0.62
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members GO Category GO:0010038 response to metal ion Database 0
Category members GO Category GO:0017137 Rab GTPase binding Database 0
Category members GO Category GO:0043015 gamma-tubulin binding Database 0
Category members GO Category GO:0045576 mast cell activation Database 0
Category members GO Category GO:0055038 recycling endosome membrane Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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