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Query: MYO5A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYO5A 0 2.648 -0.820 1.800 0.524 0.248

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYO5A Phosphorylation S600 0.774 0.889 _AIS(ph)PTSATSSGR_
MYO5A Phosphorylation S1677 0.994 0.878 _TSS(ph)IADEGTYTLDSILR_
MYO5A Ubiquitylation K1232 -1.807 _ALSEK(gl)SAPEVTAPGAPAYR_

Background Information for MYO5A:


Pubmed-MYO5A »
Uniprot-MYO5A »
Biogrid-MYO5A »
ProteomicsDB-MYO5A »

Tumorportal-MYO5A »
COSMIC-MYO5A »
GenomeRNAi-MYO5A »
Genecards-MYO5A


Protein-protein Interactions for MYO5A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AVIL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CREB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM160B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL20RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRIQ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEX19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2O Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYO5A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members Dilute IPR002710 0
Category members Myosin_S1_N IPR008989 0
Category members Skp1_comp_dimer IPR016072 0
Category members Dil_domain IPR018444 0


Protein complexes (CORUM database) featuring MYO5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MYO5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0042641 actomyosin Database 0.9
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members GO Category GO:0042438 melanin biosynthetic process Database 0.37
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0031987 locomotion involved in locomotory behavior Database 0.29
Category members GO Category GO:0030048 actin filament-based movement Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0000146 microfilament motor activity Database 0.27
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0042552 myelination Database 0.16
Category members GO Category GO:0048066 developmental pigmentation Database 0.15
Category members GO Category GO:0006582 melanin metabolic process Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0042476 odontogenesis Database 0.09
Category members GO Category GO:0050808 synapse organization Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0032252 secretory granule localization Database 0.06
Category members Pathway Pathway_1256 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 0 0
Category members Disease phenotype Griscelli_disease_type_3 Griscelli disease type 3 Database 0
Category members Disease phenotype GRISCELLI_SYNDROME_TYPE_3 GRISCELLI SYNDROME TYPE 3 Database 0
Category members GO Category GO:0001750 photoreceptor outer segment Database 0
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0007601 visual perception Database 0
Category members GO Category GO:0017137 Rab GTPase binding Database 0
Category members GO Category GO:0030073 insulin secretion Database 0
Category members GO Category GO:0030318 melanocyte differentiation Database 0
Category members GO Category GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Database 0
Category members GO Category GO:0032400 melanosome localization Database 0
Category members GO Category GO:0032402 melanosome transport Database 0
Category members GO Category GO:0032593 insulin-responsive compartment Database 0
Category members GO Category GO:0035371 microtubule plus-end Database 0
Category members GO Category GO:0042640 anagen Database 0
Category members GO Category GO:0042759 long-chain fatty acid biosynthetic process Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0


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