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Query: MTHFR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTHFR 0 -0.208 -0.450 0.210 -0.418

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for MTHFR:


Pubmed-MTHFR »
Uniprot-MTHFR »
Biogrid-MTHFR »
ProteomicsDB-MTHFR »

Tumorportal-MTHFR »
COSMIC-MTHFR »
GenomeRNAi-MTHFR »
Genecards-MTHFR


Protein-protein Interactions for MTHFR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCLRE1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDF10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD3B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNV2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMPD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIGD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM223 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF556 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MTHFR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FAD-linked_oxidoreductase-like IPR029041 0


Protein complexes (CORUM database) featuring MTHFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MTHFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0046653 tetrahydrofolate metabolic process Database 0.91
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Disease phenotype HOMOCYSTEINEMIA HOMOCYSTEINEMIA Database 0.53
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members Disease phenotype NEURAL_TUBE_DEFECTS_FOLATE-SENSITIVE NEURAL TUBE DEFECTS FOLATE-SENSITIVE Database 0.23
Category members GO Category GO:0033274 response to vitamin B2 Database 0.22
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members GO Category GO:0009086 methionine biosynthetic process Database 0.17
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members GO Category GO:0051593 response to folic acid Database 0.01
Category members Disease phenotype Cervical_spina_bifida_aperta Cervical spina bifida aperta Database 0
Category members Disease phenotype Cervical_spina_bifida_cystica Cervical spina bifida cystica Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_aperta Cervicothoracic spina bifida aperta Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_cystica Cervicothoracic spina bifida cystica Database 0
Category members Disease phenotype Isolated_anencephaly/exencephaly Isolated anencephaly/exencephaly Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_aperta Lumbosacral spina bifida aperta Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_cystica Lumbosacral spina bifida cystica Database 0
Category members Disease phenotype STROKE_ISCHEMIC STROKE ISCHEMIC Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_aperta Thoracolumbosacral spina bifida aperta Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_cystica Thoracolumbosacral spina bifida cystica Database 0
Category members Disease phenotype Total_spina_bifida_aperta Total spina bifida aperta Database 0
Category members Disease phenotype Total_spina_bifida_cystica Total spina bifida cystica Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_aperta Upper thoracic spina bifida aperta Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_cystica Upper thoracic spina bifida cystica Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0006520 cellular amino acid metabolic process Database 0
Category members GO Category GO:0006555 methionine metabolic process Database 0
Category members GO Category GO:0008015 blood circulation Database 0
Category members GO Category GO:0035999 tetrahydrofolate interconversion Database 0
Category members GO Category GO:0043200 response to amino acid Database 0
Category members GO Category GO:0046500 S-adenosylmethionine metabolic process Database 0
Category members GO Category GO:0046655 folic acid metabolic process Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0050667 homocysteine metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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