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Query: MTHFD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTHFD1 0 3.664 -0.470 0.110 0.477
MTHFD1 0 3.664 -0.470 0.110 0.256 0.731 0.774

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MTHFD1 Ubiquitylation K644 0.727 0.588 _LGK(gl)MVVASSK_
MTHFD1 Ubiquitylation K740 0.576 _FFNIK(gl)CR_
MTHFD1 Ubiquitylation K795 -0.151 _GFSNLK(gl)K_
MTHFD1 Ubiquitylation K114 0.313 _LK(gl)AAEEIGIK_
MTHFD1 Ubiquitylation K910 -0.200 _AEVYTK(gl)QGFGNLPICMAK_

Background Information for MTHFD1:


Pubmed-MTHFD1 »
Uniprot-MTHFD1 »
Biogrid-MTHFD1 »
ProteomicsDB-MTHFD1 »

Tumorportal-MTHFD1 »
COSMIC-MTHFD1 »
GenomeRNAi-MTHFD1 »
Genecards-MTHFD1


Protein-protein Interactions for MTHFD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CA10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MTHFD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Formate_THF_ligase IPR000559 0
Category members THF_DH/CycHdrlase IPR000672 0
Category members THF_DH/CycHdrlase_cat_dom IPR020630 0
Category members THF_DH/CycHdrlase_NAD-bd_dom IPR020631 0


Protein complexes (CORUM database) featuring MTHFD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MTHFD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members Disease phenotype NEURAL_TUBE_DEFECTS_FOLATE-SENSITIVE NEURAL TUBE DEFECTS FOLATE-SENSITIVE Database 0.23
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members GO Category GO:0009086 methionine biosynthetic process Database 0.17
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0009396 folic acid-containing compound biosynthetic process Database 0.09
Category members Pathway Pathway_7 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM 0 0.08
Category members Disease phenotype Cervical_spina_bifida_aperta Cervical spina bifida aperta Database 0
Category members Disease phenotype Cervical_spina_bifida_cystica Cervical spina bifida cystica Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_aperta Cervicothoracic spina bifida aperta Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_cystica Cervicothoracic spina bifida cystica Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_aperta Lumbosacral spina bifida aperta Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_cystica Lumbosacral spina bifida cystica Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_aperta Thoracolumbosacral spina bifida aperta Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_cystica Thoracolumbosacral spina bifida cystica Database 0
Category members Disease phenotype Total_spina_bifida_aperta Total spina bifida aperta Database 0
Category members Disease phenotype Total_spina_bifida_cystica Total spina bifida cystica Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_aperta Upper thoracic spina bifida aperta Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_cystica Upper thoracic spina bifida cystica Database 0
Category members GO Category GO:0000105 histidine biosynthetic process Database 0
Category members GO Category GO:0004329 formate-tetrahydrofolate ligase activity Database 0
Category members GO Category GO:0004477 methenyltetrahydrofolate cyclohydrolase activity Database 0
Category members GO Category GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0035999 tetrahydrofolate interconversion Database 0
Category members GO Category GO:0046655 folic acid metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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