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Query: MLLT4

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MLLT4 0 4.459 -1.080 1.480
MLLT4 0 4.459 -1.080 1.480 -1.880 -0.065
MLLT4 0 4.459 -1.080 1.480 0.689 0.492

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MLLT4 Phosphorylation S1275 0.682 1.367 _S(ph)QEELREDK_
MLLT4 Phosphorylation S1721 0.872 0.984 _TQVLS(ph)PDSLFTAK_
MLLT4 Phosphorylation S1779 0.084 0.426 _SQDADS(ph)PGSSGAPENLTFK_
MLLT4 Phosphorylation S216 0.045 0.221 _TIS(ph)NPEVVMK_
MLLT4 Phosphorylation S1799 0.590 0.104 _LFS(ph)QGQDVSNK_
MLLT4 Phosphorylation S1107 0.858 0.054 _QGAIYHGLATLLNQPS(ph)PMMQR_
MLLT4 Phosphorylation T1211 -0.552 _ITSVSTGNLCTEEQT(ph)PPPRPEAYPIPTQTYTR_
MLLT4 Phosphorylation S1182 -0.606 -0.764 _SSPNVANQPPS(ph)PGGK_
MLLT4 Phosphorylation S1173 -0.957 -1.174 _SS(ph)PNVANQPPS(ph)PGGK_
MLLT4 Phosphorylation S1172 -0.906 -1.359 _S(ph)SPNVANQPPS(ph)PGGK_
MLLT4 Phosphorylation S1696 -2.036 -1.851 _DYEPPS(ph)PSPAPGAPPPPPQR_
MLLT4 Phosphorylation S1698 -3.791 _DYEPPSPS(ph)PAPGAPPPPPQR_
MLLT4 Ubiquitylation K1042 -0.441 _SVVK(gl)GGAADVDGR_
MLLT4 Phosphorylation S1083 -1.359 _TSS(ph)VVTLEVAK_

Background Information for MLLT4:


Pubmed-MLLT4 »
Uniprot-MLLT4 »
Biogrid-MLLT4 »
ProteomicsDB-MLLT4 »

Tumorportal-MLLT4 »
COSMIC-MLLT4 »
GenomeRNAi-MLLT4 »
Genecards-MLLT4


Protein-protein Interactions for MLLT4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C10orf125 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEPT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ID2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MLLT4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FHA_dom IPR000253 2.3
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members SMAD_FHA_domain IPR008984 0.86
Category members PDZ IPR001478 0.15
Category members Ras-assoc IPR000159 0
Category members Dilute IPR002710 0
Category members Dil_domain IPR018444 0


Protein complexes (CORUM database) featuring MLLT4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MLLT4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0


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