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Query: MKL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MKL2 2 3.124 1.160 -0.390

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MKL2 Phosphorylation S554 1.224 1.607 _MTNNEDSLS(ph)PTSSTLSNLELDAAEKDR_
MKL2 Phosphorylation S552 1.517 _M(ox)TNNEDS(ph)LSPTSSTLSNLELDAAEKDR_

Background Information for MKL2:


Pubmed-MKL2 »
Uniprot-MKL2 »
Biogrid-MKL2 »
ProteomicsDB-MKL2 »

Tumorportal-MKL2 »
COSMIC-MKL2 »
GenomeRNAi-MKL2 »
Genecards-MKL2


Protein-protein Interactions for MKL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FHL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MKL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members RPEL_repeat IPR004018 0.09


Protein complexes (CORUM database) featuring MKL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MKL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0045844 positive regulation of striated muscle tissue development Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0048738 cardiac muscle tissue development Database 0
Category members GO Category GO:0051145 smooth muscle cell differentiation Database 0


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