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Query: MIB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MIB2 1 5.273 1.120 -0.830

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MIB2 Ubiquitylation K459 3.313 _VIGDLDTVK(gl)R_
MIB2 Phosphorylation S366 1.337 0.856 _RVS(ph)ADSQPFQHGDK_
MIB2 Ubiquitylation K899 -0.234 -0.560 _VLK(gl)ALQGCAQR_

Background Information for MIB2:


Pubmed-MIB2 »
Uniprot-MIB2 »
Biogrid-MIB2 »
ProteomicsDB-MIB2 »

Tumorportal-MIB2 »
COSMIC-MIB2 »
GenomeRNAi-MIB2 »
Genecards-MIB2


Protein-protein Interactions for MIB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MIB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_ZZ IPR000433 0.01
Category members Znf_RING IPR001841 0
Category members Ankyrin_rpt IPR002110 0
Category members Mib_Herc2 IPR010606 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring MIB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MIB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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