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Query: MARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MARS 0 2.881 0.810 -1.040 -0.620 0.302 -0.071 0.469 0.367

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MARS Ubiquitylation K109 1.248 _K(gl)GEDVLGSVR_
MARS Phosphorylation S825 -0.049 0.219 _TS(ph)PKPAVVETVTTAK_
MARS Phosphorylation T824 -0.049 0.199 _T(ph)SPKPAVVETVTTAKPQQIQALMDEVTK_
MARS Ubiquitylation K375 1.017 _ITQDIFQQLLK(gl)R_

Background Information for MARS:


Pubmed-MARS »
Uniprot-MARS »
Biogrid-MARS »
ProteomicsDB-MARS »

Tumorportal-MARS »
COSMIC-MARS »
GenomeRNAi-MARS »
Genecards-MARS


Protein-protein Interactions for MARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDCCAG8 Cat. description Hein, Mann, Cell 2015
Category members IP bait AIMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDCBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members S15_NS1_RNA-bd IPR009068 0.28
Category members WHEP-TRS IPR000738 0.27
Category members Glutathione-S-Trfase_C-like IPR010987 0.23
Category members Thioredoxin-like_fold IPR012336 0.16
Category members GST_C IPR004046 0
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Met-tRNA_synth IPR014758 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0


Protein complexes (CORUM database) featuring MARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3040 Multisynthetase complex Database 1.78


Categories featuring MARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members Disease phenotype Acute_infantile_liver_failure-multisystemic_involvement_syndrome Acute infantile liver failure-multisystemic involvement syndrome Database 0.22
Category members Pathway Pathway_299 KEGG_SELENOAMINO_ACID_METABOLISM 0 0
Category members GO Category GO:0000049 tRNA binding Database 0
Category members GO Category GO:0004825 methionine-tRNA ligase activity Database 0
Category members GO Category GO:0006431 methionyl-tRNA aminoacylation Database 0


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