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Query: LASP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LASP1 0 0.637 0.860 0.020
LASP1 0 0.637 0.860 0.020 -0.031 0.195

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LASP1 Phosphorylation S146 0.068 _MGPSGGEGMEPERRDS(ph)QDGSSYR_
LASP1 Phosphorylation T104 -1.734 _GFSVVADT(ph)PELQR_
LASP1 Ubiquitylation K42 -0.445 _MTLNMK(gl)NYK_
LASP1 Ubiquitylation K75 0.405 _LK(gl)QQSELQSQVR_

Background Information for LASP1:


Pubmed-LASP1 »
Uniprot-LASP1 »
Biogrid-LASP1 »
ProteomicsDB-LASP1 »

Tumorportal-LASP1 »
COSMIC-LASP1 »
GenomeRNAi-LASP1 »
Genecards-LASP1


Protein-protein Interactions for LASP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PRKCZ Cat. description Hein, Mann, Cell 2015
Category members IP bait C11orf65 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYTTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFYA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OR10H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RDH12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THAP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LASP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members Nebulin_repeat IPR000900 0.07
Category members SH3_domain IPR001452 0
Category members Znf_LIM IPR001781 0


Protein complexes (CORUM database) featuring LASP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LASP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006811 ion transport Database 0.18
Category members GO Category GO:0030864 cortical actin cytoskeleton Database 0.06
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0
Category members GO Category GO:0015075 ion transmembrane transporter activity Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0


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