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Query: KLC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KLC1 0 1.947 -0.330 0.080
KLC1 0 1.947 -0.330 0.080 1.524

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KLC1 Phosphorylation S152 0.911 0.956 _S(ph)RESLNVDVVK_
KLC1 Phosphorylation S155 0.730 0.916 _SRES(ph)LNVDVVK_
KLC1 Phosphorylation S230 0.584 0.849 _RAS(ph)SLNVLNVGGK_
KLC1 Phosphorylation S231 0.511 0.647 _ASS(ph)LNVLNVGGK_
KLC1 Phosphorylation S66 -0.049 0.154 _VDS(ph)PTVTTTLK_

Background Information for KLC1:


Pubmed-KLC1 »
Uniprot-KLC1 »
Biogrid-KLC1 »
ProteomicsDB-KLC1 »

Tumorportal-KLC1 »
COSMIC-KLC1 »
GenomeRNAi-KLC1 »
Genecards-KLC1


Protein-protein Interactions for KLC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF5B Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAP1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AZIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KPTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KLC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members Rabaptin_Rab5-bd_dom IPR015390 0.21
Category members Kinesin_light IPR002151 0.16


Protein complexes (CORUM database) featuring KLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring KLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0005874 microtubule Database 1.21
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_1314 REACTOME_KINESINS 0 0.32
Category members GO Category GO:0005871 kinesin complex Database 0.27
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0035617 stress granule disassembly Database 0.15
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0035253 ciliary rootlet Database 0.03
Category members GO Category GO:0008088 axon cargo transport Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0035418 protein localization to synapse Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0


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