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Query: ITSN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITSN2 0 2.660 -0.710 0.950 0.287 0.672

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITSN2 Ubiquitylation K583 0.151 _NMQFSNTPDSGVSLLHK(gl)K_
ITSN2 Phosphorylation S889 -0.357 -0.319 _TVSPGSVS(ph)PIHGQGQVVENLK_
ITSN2 Ubiquitylation K584 -0.412 _NMQFSNTPDSGVSLLHKK(gl)_
ITSN2 Ubiquitylation K596 1.277 _LK(gl)EQLDALEK_

Background Information for ITSN2:


Pubmed-ITSN2 »
Uniprot-ITSN2 »
Biogrid-ITSN2 »
ProteomicsDB-ITSN2 »

Tumorportal-ITSN2 »
COSMIC-ITSN2 »
GenomeRNAi-ITSN2 »
Genecards-ITSN2


Protein-protein Interactions for ITSN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EZH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MRPL9 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTEN Cat. description Hein, Mann, Cell 2015
Category members IP bait RNF41 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TM9SF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITSN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members SH3_2 IPR011511 0.08
Category members DH-domain IPR000219 0.05
Category members C2_dom IPR000008 0
Category members EPS15_homology IPR000261 0
Category members SH3_domain IPR001452 0
Category members EF_hand_dom IPR002048 0
Category members Spectrin_alpha_SH3 IPR013315 0


Protein complexes (CORUM database) featuring ITSN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ITSN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0


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