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Query: ISL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ISL2 0 -2.348 0.170 -0.540 0.032

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ISL2 Phosphorylation S157 -0.640 -0.776 _S(ph)PGPLPGAR_
ISL2 Ubiquitylation K201 -0.430 -1.275 _TVLNEK(gl)QLHTLR_
ISL2 Phosphorylation S279 0.101 _TSLQGLTGTPLVAGS(ph)PIR_

Background Information for ISL2:


Pubmed-ISL2 »
Uniprot-ISL2 »
Biogrid-ISL2 »
ProteomicsDB-ISL2 »

Tumorportal-ISL2 »
COSMIC-ISL2 »
GenomeRNAi-ISL2 »
Genecards-ISL2


Protein-protein Interactions for ISL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARIH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IDI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LHX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSBP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSBP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ISL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members Znf_LIM IPR001781 0
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring ISL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ISL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0021524 visceral motor neuron differentiation Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0021520 spinal cord motor neuron cell fate specification Database 0
Category members GO Category GO:0031290 retinal ganglion cell axon guidance Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0048935 peripheral nervous system neuron development Database 0


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